1400755-05-6 Usage
Description
(2-methyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)methanol is a boronic acid derivative that serves as a versatile building block in organic synthesis and medicinal chemistry. It is characterized by its ability to form stable complexes with diols and other compounds, which makes it a valuable tool for the selective recognition and sensing of biomolecules. Its unique reactivity and stability have also attracted interest in material science and catalysis applications.
Uses
Used in Organic Synthesis:
(2-methyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)methanol is used as a building block for the synthesis of complex organic molecules, particularly in the development of pharmaceuticals and agrochemicals. Its reactivity allows for the formation of stable complexes with diols and other compounds, facilitating the creation of diverse molecular structures.
Used in Medicinal Chemistry:
In the field of medicinal chemistry, (2-methyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)methanol is employed as a key intermediate in the synthesis of bioactive compounds. Its ability to form stable complexes with biomolecules makes it a promising candidate for the development of drugs with selective targeting capabilities.
Used in Material Science:
(2-methyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)methanol is utilized in material science for the development of novel materials with unique properties. Its reactivity and stability contribute to the creation of materials with enhanced performance characteristics, such as improved mechanical strength or thermal stability.
Used in Catalysis:
In the field of catalysis, (2-methyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)methanol is studied for its potential as a catalyst or catalyst support. Its unique reactivity and stability may enable the development of more efficient and selective catalytic processes for various chemical reactions.
Used in Biomolecular Recognition and Sensing:
(2-methyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)methanol is used as a tool for the selective recognition and sensing of biomolecules. Its ability to form stable complexes with diols and other compounds allows for the development of sensors and diagnostic tools with high specificity and sensitivity.
Check Digit Verification of cas no
The CAS Registry Mumber 1400755-05-6 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,4,0,0,7,5 and 5 respectively; the second part has 2 digits, 0 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 1400755-05:
(9*1)+(8*4)+(7*0)+(6*0)+(5*7)+(4*5)+(3*5)+(2*0)+(1*5)=116
116 % 10 = 6
So 1400755-05-6 is a valid CAS Registry Number.
1400755-05-6Relevant articles and documents
Design, synthesis, evaluation, and SAR of 4-phenylindoline derivatives, a novel class of small-molecule inhibitors of the programmed cell death-1/ programmed cell death-ligand 1 (PD-1/PD-L1) interaction
Yang, Yang,Wang, Ke,Chen, Hao,Feng, Zhiqiang
, (2021)
The blockade of the PD-1/PD-L1 immune checkpoint pathway with small molecules is an emerging immunotherapeutic approach. A novel series of 4-phenylindoline derivatives were synthesized, and their inhibitory activity against the PD-1/PD-L1 protein-protein interaction (PPI) was evaluated through a homogenous time-resolved fluorescence (HTRF) assay. Among them, A20 and A22 exhibited potent activity with IC50 values of 17 nM and 12 nM, respectively. Furthermore, A20 showed the promising inhibitory activity against the PD-1/PD-L1 interaction with the EC50 value of 0.43 μM in a co-culture model of PD-L1/TCR Activator-expressing CHO cells and PD-1-expressing Jurkat cells. Besides, the structure?activity relationships (SAR) of the novel synthesized 4-phenylindoline derivatives was concluded, and the binding mode of A22 with the PD-L1 dimer was analyzed by molecular simulation and docking, demonstrating that the N-atom in the side chain of indoline fragment could interact with the amino acid residue of the PD-L1 protein to lead to the potent inhibitory activity. This study provided a new insight for further drug design.
Biphenyl compound as immunoregulator and applications of same
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Paragraph 0165-0169, (2020/03/17)
The invention relates to a biphenyl compound as the formula (I), and a preparation method and a pharmaceutical application thereof. The groups in the formula (I) are defined as the specification. Thecompound can block the interaction between PD-1/PD-L1 si
PD-1/PD-L1 INHIBITORS
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Page/Page column 211; 214, (2018/11/22)
Compounds according to formula (I), methods of using said compounds singly or in combination with additional agents and compositions of said compounds for the treatment of cancer are disclosed.
