1400813-90-2Relevant academic research and scientific papers
Fused dual boron core based BODIPY dyes: synthesis and optical character
Wang, Linlin,Qu, Yi,Xu, Jingli,Cao, Jian,Zhao, Chunchang
, p. 1605 - 1609 (2016)
Here we report that two boron dipyrromethene derivatives (BNB-1 and BNB-2), bearing double boron atomic centers, have been synthesized and characterized. The additional boron atom was introduced into the skeleton of typical BODIPY dyes through the reactio
Near-infrared fluorescent dyes with large Stokes shifts: Light generation in BODIPYs undergoing excited state intramolecular proton transfer
Fei, Qiang,Gu, Xianfeng,Liu, Yajing,Shi, Ben,Liu, Hengyan,Xu, Ge,Li, Chunbao,Shi, Ping,Zhao, Chunchang
, p. 4072 - 4076 (2017/07/10)
Novel BODIPYs undergoing excited state intramolecular proton transfer are reported. The molecules afford NIR emission with a large Stokes shift and possess a free hydroxyl unit that is easy to functionalize, allowing the dyes to be exploited as a valuable scaffold in probe design.
SPIROBODIPYs with spiropyran structure compound, preparation method and its use
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, (2016/11/02)
The invention discloses a SPIROBODIPYs compound with the spiropyrane structure. The compound has the following structural general formula (refer to the Specification), wherein R1, R2, R3 and R4 are alkyl substituents or aromatic substituents, R5 is an alkyl substituent, an alcohol hydroxyl substituent or a substituent with triple bonds at the tail end. The invention further discloses the application of the SPIROBODIPYs compound to a fluorescence molecular probe. The SPIROBODIPYs compound can be applied to controllable detection of physiological and pathological process of cells, and can be used for building living cell acid organelles or used as a novel fluorescent dye of a fluorescence molecular probe for detecting the acid environment of cancer cells.
Target-triggered NIR emission with a large stokes shift for the detection and imaging of cysteine in living cells
Zhao, Chunchang,Li, Xiuai,Wang, Feiyi
, p. 1777 - 1781 (2014/07/08)
Background autofluorescence from biological systems generally reduces the sensitivity of a fluorescent probe for imaging biological targets. Addressing this challenge requires the development of fluorescent probes that produce emission in the near-infrared region. Herein, we report the design and synthesis of a fluorescent probe that generates an NIR emission with a large Stokes shift upon the selective response to Cys over Hcy and GSH. The probe is designed to consist of two Cys-sensing sites, an acrylate ester and an aldehyde installed ortho to each other. The reaction of the probe with Cys triggers an excited state intramolecular proton transfer process upon photo-excitation, thereby producing an NIR emission with a large Stokes shift. Accordingly, this probe hold great promise for the selective detection of Cys in biological systems. We further demonstrate the capacity of this probe for Cys imaging in living cells. How exciting! The reaction of the fluorescent probe PCys-B with cysteine (Cys) triggers an excited state intramolecular proton transfer process upon photoexcitation, thus producing an NIR emission with a large Stokes shift. This makes the probe promising for the selective detection of Cys in biological systems.
Target-triggered deprotonation of 6-hydroxyindole-based BODIPY: Specially switch on NIR fluorescence upon selectively binding to Zn2+
Cao, Jian,Zhao, Chunchang,Wang, Xuzhe,Zhang, Yanfen,Zhu, Weihong
supporting information, p. 9897 - 9899 (2012/11/07)
Based on 6-hydroxyindole BODIPY with a Schiff-base structure, NIR fluorescence with impressively high selectivity is triggered by deprotonation of the phenol group upon binding with Zn2+ due to the chelation-enhanced fluorescence effect, thus realizing a promising application in bioimaging of Zn2+. The Royal Society of Chemistry 2012.
