1400815-02-2

Basic information

• Product Name: 4’-C-azidomethyl-3’,5’-di-O-benzyl-3-(4-methoxybenzyl)-2’-O-methylthymidine
• Synonyms: 4’-C-azidomethyl-3’,5’-di-O-benzyl-3-(4-methoxybenzyl)-2’-O-methylthymidine
• CAS NO: 1400815-02-2
• Molecular Weight: 627.697
• Mol File: 1400815-02-2.mol

Chemical Properties

• CAS DataBase Reference: 4’-C-azidomethyl-3’,5’-di-O-benzyl-3-(4-methoxybenzyl)-2’-O-methylthymidine(CAS DataBase Reference)
• NIST Chemistry Reference: 4’-C-azidomethyl-3’,5’-di-O-benzyl-3-(4-methoxybenzyl)-2’-O-methylthymidine(1400815-02-2)
• EPA Substance Registry System: 4’-C-azidomethyl-3’,5’-di-O-benzyl-3-(4-methoxybenzyl)-2’-O-methylthymidine(1400815-02-2)

Safety Data

• Hazardous Substances Data: 1400815-02-2(Hazardous Substances Data)

Upstream product

• 74-88-4 methyl iodide 
• 1400815-01-1 2’-O-acetyl-4’-C-azidomethyl-3’,5’-di-O-benzyl-3-(4-methoxybenzyl)thymidine 
• 250708-41-9 1-{2-O-acetyl-5-azido-3-O-benzyl-4-[(benzyloxy)methyl]-5-deoxy-α-L-lyxothranosyl}-5-methylpyrimidine-2,4-(1H,3H)-dione 
• 824-94-2 p-methoxybenzyl chloride 

Downstream Products

• 250708-37-3 1-{5-amino-3-O-benzyl-4-C-[(benzyloxy)methyl]-5-deoxy-2-O-methyl-α-L-lyxofuranosyl}thymine 
• 250708-44-2 1-{5-azido-3-O-benzyl-4-C-[(benzyloxy)methyl]-5-deoxy-2-O-methyl-α-L-lyxofuranosyl}thymine 
• 250708-40-8 1-{3-O-benzyl-4-C-[(benzyloxy)methyl]-5-deoxy-2-O-methyl-5-[(trifluoroacetyl)amino]-α-L-lyxofuranosyl}thymine 

Relevant articles and documents

Incorporation of 4′-C-aminomethyl-2′-O-methylthymidine into DNA by thermophilic DNA polymerases

The dual modified nucleotide 4′-C-aminomethyl-2′-O- methylthymidine 5′-triphosphate was synthesized and enzymatically incorporated into DNA by the thermophilic DNA polymerases Pfu and Therminator III. The dual ribose modification imparted increased exonuclease resistance to DNA compared to the well-known 2′-O-methyl modification.