1400816-06-9

Upstream product

• 129696-79-3 2-Methyl-benzoic acid 6-acetyl-2-cyano-3,4-dimethyl-phenyl ester 
• 89638-56-2 3-cyano-4,5-dimethyl-2-hydroxyacetophenone 
• 129697-02-5 6,7-Dimethyl-4-oxo-2-o-tolyl-4H-chromene-8-carboxylic acid 
• 18107-18-1 diazomethyl-trimethyl-silane 
• 129697-13-8 6,7-Dimethyl-4-oxo-2-o-tolyl-4H-chromene-8-carbonitrile 

Relevant academic research and scientific papers

Cell death triggered by synthetic flavonoids in human leukemia cells is amplified by the inhibition of extracellular signal-regulated kinase signaling

A new class of methyl esters of flavonoids, with different substituents on the B ring were synthesized and evaluated for their antiproliferative activity against the human leukemia cell line HL-60. The presence of either a methyl group (1f) or a chlorine atom (1o) at position 2′ of the B ring played an important role in affecting antiproliferative activity. The cytotoxic effects of these compounds were accompanied by the concentration- and time-dependent appearance of DNA- and nuclear-fragmentation, increase in the percentage of sub-G1 cells, and processing of multiple caspases and poly(ADP-ribose)polymerase cleavage. Pretreatment of cells with the specific mitogen-activated extracellular kinases (MEK) 1/2 inhibitor PD98059, together with 1f and 1o, resulted in an important enhancement of cell death, which might have clinical implications for the use of both compounds in combination with MEK 1/2 inhibitors as potential therapeutic agents.