89638-56-2

Upstream product

• 5117-88-4 2-amino-3-cyano-4,5-dimethylfuran 
• 78-94-4 methyl vinyl ketone 

Downstream Products

• 129696-75-9 4-Fluoro-benzoic acid 6-acetyl-2-cyano-3,4-dimethyl-phenyl ester 
• 129696-76-0 2-Chloro-benzoic acid 6-acetyl-2-cyano-3,4-dimethyl-phenyl ester 
• 129696-73-7 3-Methoxy-benzoic acid 6-acetyl-2-cyano-3,4-dimethyl-phenyl ester 
• 129696-70-4 3-cyano-4,5-dimethyl-2-benzoyloxyacetophenone 
• 129696-72-6 4-Methoxy-benzoic acid 6-acetyl-2-cyano-3,4-dimethyl-phenyl ester 
• 129696-79-3 2-Methyl-benzoic acid 6-acetyl-2-cyano-3,4-dimethyl-phenyl ester 
• 129696-80-6 3-Methyl-benzoic acid 6-acetyl-2-cyano-3,4-dimethyl-phenyl ester 
• 129696-81-7 α-benzoyl-2-hydroxy-3-cyano-4,5-dimethylacetophenone 
• 129697-04-7 8-cyano-6,7-dimethylflavone 
• 129697-14-9 6,7-Dimethyl-4-oxo-2-m-tolyl-4H-chromene-8-carbonitrile 
• 129697-08-1 6,7-Dimethyl-4-oxo-2-p-tolyl-4H-chromene-8-carbonitrile 
• 129696-85-1 2-Hydroxy-5,6-dimethyl-3-(3-oxo-3-p-tolyl-propionyl)-benzonitrile 
• 129696-90-8 2-Hydroxy-5,6-dimethyl-3-(3-oxo-3-m-tolyl-propionyl)-benzonitrile 
• 129696-91-9 8-carboxamido-6,7-dimethylflavone 

Relevant academic research and scientific papers

Cell death triggered by synthetic flavonoids in human leukemia cells is amplified by the inhibition of extracellular signal-regulated kinase signaling

A new class of methyl esters of flavonoids, with different substituents on the B ring were synthesized and evaluated for their antiproliferative activity against the human leukemia cell line HL-60. The presence of either a methyl group (1f) or a chlorine atom (1o) at position 2′ of the B ring played an important role in affecting antiproliferative activity. The cytotoxic effects of these compounds were accompanied by the concentration- and time-dependent appearance of DNA- and nuclear-fragmentation, increase in the percentage of sub-G1 cells, and processing of multiple caspases and poly(ADP-ribose)polymerase cleavage. Pretreatment of cells with the specific mitogen-activated extracellular kinases (MEK) 1/2 inhibitor PD98059, together with 1f and 1o, resulted in an important enhancement of cell death, which might have clinical implications for the use of both compounds in combination with MEK 1/2 inhibitors as potential therapeutic agents.

FURAN o-AMINONITRILES AS PRECURSORS TO FLAVONE ANALOGUES

A procedure utilizing furan o-aminonitriles as precursors in the synthesis of substituted flavone analogues is reported.The key intermediates, o-hydroxyacetophenones, are obtained by a Diels-Alder reaction between the furans and methyl vinyl ketone.

Synthesis of Previously Inaccessible Quinazolines and 1,4-Benzodiazepines as Potential Anticonvulsants

A series of 4,6,7,8-tetrasubstituted 3,4-dihydroquinazolines, quinazolines, quinazolin-2-ones, 1,2,3,4-tetrahydroquinazolin-2-ones, and 5,7,8,9-tetrasubstituted 1,4-benzodiazepines have been synthesized by utilizing the Diels-Alder reaction between furan