1400898-77-2Relevant academic research and scientific papers
Convenient approach for the one-pot, three-component synthesis of triheterocyclic 4 H-pyrimido[2,1-b]benzothiazole derivatives using TBAHS
Nagarapu, Lingaiah,Gaikwad, Hanmant K.,Palem, Jyothsna Devi,Venkatesh, Ramineni,Bantu, Rajashaker,Sridhar
, p. 93 - 104 (2013)
An efficient and convenient synthesis of 4H-pyrimido[2,1-b]benzothiazole derivatives has been achieved by a one-pot, three-component condensation reaction of 2-aminobenzothiazole (1) with substituted benzaldehydes (2a-f) and -dicarbonyl derivatives (3a-e) in presence of 30mol% of tetrabutylammonium hydrogen sulfate (TBAHS) in good to excellent yields. Copyright Taylor & Francis Group, LLC.
Combining photo-redox and enzyme catalysis for the synthesis of 4H-pyrimido[2,1-b] benzothiazole derivatives in one pot
Yu, Yuan,Lu, Wei-Fan,Yang, Zeng-Jie,Wang, Na,Yu, Xiao-Qi
, (2020/12/25)
A novel strategy combining visible-light and enzyme catalysis in one pot for the synthesis of 4H-pyrimido[2,1-b] benzothiazole derivatives from alcohols is described for the first time. Fourteen 4H-pyrimido[2,1-b] benzothiazole derivatives were prepared with yields of up to 98% under mild reaction conditions by a simple operation. The photoorgano catalyst rose Bengal (rB) was employed to oxyfunctionalise alcohols to aldehydes. Compared with aldehydes, alcohols with more stable properties and lower cost, thus we used photocatalysis to oxidize alcohols into aldehydes. Next, the enzyme was used to further catalyze the reaction of Biginelli to produce the target product of 4H-pyrimidine [2,1-b] benzothiazole. Experimental results show that this method provides a more efficient and eco-friendly strategy for the synthesis of 4H-pyrimido[2,1-b] benzothiazole derivatives.
A simple approach to the one-pot three component synthesis of 4hpyrimido [2,1-b] benzothiazole derivatives using polyethylene glycol (PEG-400)
Rairala, Prabhakar,Yadagiri, Bandi,Bantu, Rajashaker,Guguloth, Vijayacharan,Nagarapu, Lingaiah
, p. 197 - 204 (2015/06/22)
PEG-400 was found to be an inexpensive, non-toxic and eco-friendly reaction medium for synthesis of pyramido[ 2,1-b]benzothiazole derivatives. Utilizing this protocol, we are capable of various pyrimido[2,1-b]benzothiazole derivatives 4a-k and 6a-d were s
