14009-34-8 Usage
Uses
Used in Anticancer Applications:
Nimustine is used as a chemotherapy agent for the treatment of various types of cancer, including brain tumors and lymphomas. It is effective due to its ability to penetrate the blood-brain barrier, making it a crucial drug in cases where cancer has spread to the brain.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, Nimustine is used as an active ingredient in the development of cancer treatment drugs. Its alkylating properties and DNA-damaging mechanism contribute to its role in combating cancer cells.
Used in Research and Development:
Nimustine is also utilized in research and development for the study of cancer biology, drug resistance, and the development of novel cancer therapies. Its unique ability to cross the blood-brain barrier makes it a valuable compound for exploring new treatment strategies for brain tumors and other central nervous system malignancies.
Check Digit Verification of cas no
The CAS Registry Mumber 14009-34-8 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,4,0,0 and 9 respectively; the second part has 2 digits, 3 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 14009-34:
(7*1)+(6*4)+(5*0)+(4*0)+(3*9)+(2*3)+(1*4)=68
68 % 10 = 8
So 14009-34-8 is a valid CAS Registry Number.
14009-34-8Relevant academic research and scientific papers
1-Aryl-3-(2-chloroethyl) ureas: Synthesis and in vitro assay as potential anticancer agents
Gaudreault,lacroix,Page,Joly
, p. 185 - 187 (2007/10/02)
1-Aryl-3-(2-chlorethyl) ureas and 1-aryl-3-nitrose-3-(2-chloroethyl) ureas, derived from 4-phenylbutyric acid and alkylanillines, were synthesized and their cytotoxicity was evaluated on human adenocarcinoma cells in vitro. Methyl 4-[p-[3-(2-chloroethyl)ureido]-phenyl]butyrate, 4-methyl [3-(2-chloroethyl)ureido]benzene, and 4-butyl[3-(2-chloroethyl)ureido]benzene were found to be at least as cytotoxic as 4-[p-[bis-(2-chloroethyl)amino]phenyl]butyric acid (chlorambucil), while their N-nitrose derivatives were inactive.
