14009-34-8 Usage
Description
1-(2-chloroethyl)-3-(4-methylphenyl)-1-nitrosourea, commonly known as Nimustine, is a nitrosourea alkylating agent utilized in chemotherapy for the treatment of various cancer types. It is particularly effective against brain tumors and lymphomas due to its ability to penetrate the blood-brain barrier. Nimustine works by damaging the DNA of cancer cells, leading to their death. Despite its effectiveness, it may cause side effects such as bone marrow suppression, nausea, and vomiting.
Uses
Used in Anticancer Applications:
Nimustine is used as a chemotherapy agent for the treatment of various types of cancer, including brain tumors and lymphomas. It is effective due to its ability to penetrate the blood-brain barrier, making it a crucial drug in cases where cancer has spread to the brain.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, Nimustine is used as an active ingredient in the development of cancer treatment drugs. Its alkylating properties and DNA-damaging mechanism contribute to its role in combating cancer cells.
Used in Research and Development:
Nimustine is also utilized in research and development for the study of cancer biology, drug resistance, and the development of novel cancer therapies. Its unique ability to cross the blood-brain barrier makes it a valuable compound for exploring new treatment strategies for brain tumors and other central nervous system malignancies.
Check Digit Verification of cas no
The CAS Registry Mumber 14009-34-8 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,4,0,0 and 9 respectively; the second part has 2 digits, 3 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 14009-34:
(7*1)+(6*4)+(5*0)+(4*0)+(3*9)+(2*3)+(1*4)=68
68 % 10 = 8
So 14009-34-8 is a valid CAS Registry Number.
14009-34-8Relevant articles and documents
1-Aryl-3-(2-chloroethyl) ureas: Synthesis and in vitro assay as potential anticancer agents
Gaudreault,lacroix,Page,Joly
, p. 185 - 187 (2007/10/02)
1-Aryl-3-(2-chlorethyl) ureas and 1-aryl-3-nitrose-3-(2-chloroethyl) ureas, derived from 4-phenylbutyric acid and alkylanillines, were synthesized and their cytotoxicity was evaluated on human adenocarcinoma cells in vitro. Methyl 4-[p-[3-(2-chloroethyl)ureido]-phenyl]butyrate, 4-methyl [3-(2-chloroethyl)ureido]benzene, and 4-butyl[3-(2-chloroethyl)ureido]benzene were found to be at least as cytotoxic as 4-[p-[bis-(2-chloroethyl)amino]phenyl]butyric acid (chlorambucil), while their N-nitrose derivatives were inactive.
