14010-45-8Relevant academic research and scientific papers
Design and optimisation of selective serotonin re-uptake inhibitors with high synthetic accessibility: Part 2
Andrews, Mark,Brown, Alan,Chiva, Jean-Yves,Fradet, David,Gordon, David,Lansdell, Mark,MacKenny, Malcolm
scheme or table, p. 5893 - 5897 (2010/07/07)
A second wave of potential SSRIs with high ease of synthetic accessibility were designed based on the reported selective serotonin re-uptake inhibitor litoxetine and our own previous work in this area. Preparation and subsequent optimisation yielded a ran
Reductive Dechlorination of Chloro-phenols and -benzoic acids by Raney Co-Al Alloy in an Alkaline Deuterium Oxide Solution and Preparation of Deuterated Salicylic Acids
Tashiro, Masashi,Tsuzuki, Hirohisa,Matsumoto, Jun-ichi,Mataka, Shuntaro,Nakayama, Kouji,et al.
, p. 2826 - 2851 (2007/10/02)
Reduction of monochloro-phenols (1a-c) and -benzoic acids (3a-c) by using Raney Co-Al alloy in 10percent NaOD-D2O gave phenols (2a-c) and benzoic acids (4a-c) in 86-93percent isotopic purities.The reduction of di-, tri-, and tetra-chlorinated derivatives, (1) and (3), gave the deuteriated products, (2) and (4), in somewhat low isotopic purities (70-84percent).In the reduction of polychlorinated benzoic acids (3), the use of a mixed solution (1/1 = v/v) of 10percent Na2CO3-D2O and 10percent NaOD-D2O was effective and gave 4 in 80-89percent isotopic purities.The treatment of chlorosalicylic acids (5) with Raney Co-Al alloy in 10percent NaOD-D2O gave 1> (6) - 3> (6) in 91-93percent isotopic purities.
