1401009-25-3Relevant academic research and scientific papers
Palladium-catalyzed allylic fluorination of cinnamyl phosphorothioate esters
Lauer, Andrew M.,Wu, Jimmy
supporting information, p. 5138 - 5141,4 (2012/12/12)
A highly regioselective, Pd-catalyzed allylic fluorination of phosphorothioate esters is reported. This chemistry addresses several limitations of previously reported methods in which elimination and lack of reactivity were problematic. Preliminary mechanistic investigations reveal that these reactions are stereospecific and provide fluorinated products with net retention of stereochemical configuration. In analogy to other Pd-catalyzed allylic substitution reactions, this process likely proceeds through a palladium π-allyl intermediate.
Palladium-catalyzed allylic fluorination of cinnamyl phosphorothioate esters
Lauer, Andrew M.,Wu, Jimmy
supporting information, p. 5138 - 5141 (2013/01/15)
A highly regioselective, Pd-catalyzed allylic fluorination of phosphorothioate esters is reported. This chemistry addresses several limitations of previously reported methods in which elimination and lack of reactivity were problematic. Preliminary mechanistic investigations reveal that these reactions are stereospecific and provide fluorinated products with net retention of stereochemical configuration. In analogy to other Pd-catalyzed allylic substitution reactions, this process likely proceeds through a palladium π-allyl intermediate.
