1401088-99-0Relevant academic research and scientific papers
Synthesis of tubuphenylalanines via ireland-claisen rearrangement
Becker, Dominic,Kazmaier, Uli
, p. 59 - 65 (2013/03/28)
The Ireland-Claisen rearrangement is the central step in the synthesis of tubuphenylalanine, a key building block of the highly antitumor-active tubulysins. The rearrangement of substituted β-amino acid allyl esters, in combination with subsequent decarboxylation and oxidative cleavage of the double bond, allows the highly stereoselective introduction of substituents into the α-position of the resulting σ-amino acids.
