1401227-95-9Relevant academic research and scientific papers
Catalytic asymmetric Mannich reaction of glycine Schiff bases with α-amido sulfones as precursors of aliphatic imines
Hernando, Elier,Arrayas, Ramon Gomez,Carretero, Juan C.
supporting information, p. 9622 - 9624 (2012/11/07)
A general and practical CuI-Fesulphos-catalyzed Mannich reaction of glycinate Schiff bases with aliphatic imines generated in situ from α-amido sulfones is described. Imines with linear and branched alkyl chains, including substrates bearing functional groups, can be efficiently applied. The resulting syn-configured orthogonally protected β-alkyl-α,β-diamino acid derivatives are produced with excellent levels of diastereo- (typically syn/anti >90:10) and enantioselectivity (generally ≥90% ee).
