1401236-55-2Relevant academic research and scientific papers
Transferring oxygen isotopes to 1,2,4-benzotriazine 1-oxides forming the corresponding 1,4-dioxides by using the HOF·CH3CN complex
Gatenyo, Julia,Johnson, Kevin,Rajapakse, Anuruddha,Gates, Kent S.,Rozen, Shlomo
, p. 8942 - 8944 (2012)
Heterocyclic benzotriazine N-oxides are an interesting class of experimental anticancer and antibacterial agents. Analogs with 18O incorporated into the N-oxide group may offer useful mechanistic tools. We describe the use of H218OF·CH3CN in a fast, readily executed and high-yielding preparation of 1,2,4-benzotriazine 1,4-dioxides containing an 18O-label at the 4-oxide position.
