1401302-51-9Relevant academic research and scientific papers
Design of Selective Benzoxazepin PI3Kδ Inhibitors Through Control of Dihedral Angles
Safina, Brian S.,Elliott, Richard L.,Forrest, Andrew K.,Heald, Robert A.,Murray, Jeremy M.,Nonomiya, Jim,Pang, Jodie,Salphati, Laurent,Seward, Eileen M.,Staben, Steven T.,Ultsch, Mark,Wei, Binqing,Yang, Wenqian,Sutherlin, Daniel P.
, p. 936 - 940 (2017)
A novel selective benzoxazepin inhibitor of PI3Kδ has been discovered. Beginning from compound 3, an αPI3K inhibitor, we utilized structure-based drug design and computational analysis of dihedral torsion angles to optimize for PI3Kδ isoform potency and isoform selectivity. Further medicinal chemistry optimization of the series led to the identification of 24, a highly potent and selective inhibitor of PI3Kδ.
BENZOXAZEPIN COMPOUNDS SELECTIVE FOR PI3K P110 DELTA AND METHODS OF USE
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Page/Page column 134, (2012/10/08)
Benzoxazepin Formula I compounds, including stereoisomers, geometric isomers, tautomers, metabolites and pharmaceutically acceptable salts thereof, are useful for inhibiting the delta isoform of PI3K, and for treating disorders mediated by lipid kinases such as inflammation, immunological disorders, and cancer. Methods of using compounds of Formula I for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions, are disclosed.
