1401333-75-2

Upstream product

• 882307-62-2 C₁₈H₂₇N₃O₂ 
• 16331-45-6 p-ethylbenzoyl chloride 
• 192130-34-0 tert-butyl 4-(2-aminoethyl)piperazine-1-carboxylate 
• 100450-84-8 N-[phenylmethylidene]-2-piperazin-1-ylethanamine 
• 140-31-8 aminoethylpiperazine 

Downstream Products

• 1401333-77-4 C₁₅H₂₃N₃O*ClH 
• 1401333-82-1 C₂₃H₃₁N₃O 
• 1401333-87-6 C₂₄H₃₃N₃O 

Relevant academic research and scientific papers

The design and synthesis of 1,4-substituted piperazine derivatives as triple reuptake inhibitors

Novel 1,4-substituted piperazine derivatives 5, Series A and B were designed by fragment analysis and molecular modification of 4 selected piperazine-containing compounds which possess antidepressant activity. We synthesized new 39 analogues of Series A and 10 compounds of Series B, respectively. The antidepressant screening against DA, NE, and serotonin neurotransmitter uptake inhibition was carried out using the Neurotransmitter Transporter Uptake Assay Kit. The compounds in Series B showed relatively higher reuptake inhibitory activity for SERT, NET, and DAT than those in Series A. The length of spacer between the central piperazine core and the terminal phenyl ring substituted at the piperazine ring in Series B seems to exert an important role in the activity.