140135-72-4Relevant academic research and scientific papers
A NEW METHOD OF 18F LABELLING AND INTERMEDIATE SALTS
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, (2021/06/26)
Disclosed herein is a salt of formula I: where R1, X, n, R, R1, Y, m, p, q, Z and o are as defined herein. Also disclosed herein are methods of using said salts in chemical synthesis, such as to prepare compounds isotopically enriched in 18F for use in PET imaging, as well as methods to make the compounds of formula I.
Frustrated Lewis-Pair-Meditated Selective Single Fluoride Substitution in Trifluoromethyl Groups
Gupta, Richa,Jaiswal, Amit K.,Mandal, Dipendu,Young, Rowan D.
, p. 2572 - 2578 (2020/03/03)
Single fluoride substitution in trifluoromethylarenes is an ongoing synthetic challenge that often leads to "over-reaction", where multiple fluorides are replaced. Development of this reaction would allow simple access to a vast range of difluoromethyl derivatives of current interest to pharmaceutical, agrochemistry, and materials sciences. Using a catalytic frustrated Lewis pair approach, we have developed a generic protocol that allows a single substitution of one fluoride in trifluoromethyl groups with neutral phosphine and pyridine bases. The resulting phosphonium and pyridinium salts can be further functionalized via nucleophilic substitution, photoredox coupling, and electrophilic transfer reactions allowing the generation of a vast array of difluoromethyl products.
Convenient Preparation of (Chlorodifluoromethyl)arenes. Useful Precursors for Aryldifluoromethyl Radicals
Yoshida, Masato,Morinaga, Yoshihiro,Ueda, Masaaki,Kamigata, Nobumasa,Iyoda, Masahiko
, p. 227 - 230 (2007/10/02)
Chlorodifluoromethyl group was introduced into aromatic rings using bis(chlorodifluoroacetyl) peroxide which was readily prepared from corresponding acid anhydride with 30percent hydrogen peroxide, and the chlorine was successively replaced by hydrogen or
