1401413-70-4

Upstream product

• 14131-63-6 D-glucosamine hydrochloride 
• 122210-05-3 1,3,4,6-tetra-O-acetyl-2-deoxy-2-(2,2,2-trichloroethoxycarbonylamino)-β-D-glucopyranose 
• 1401413-63-5 C₂₂H₂₆Cl₃NO₁₁ 
• 1401413-64-6 C₁₉H₂₅NO₉ 
• 1259298-28-6 4-methoxyphenyl 3,4,6-tri-O-acetyl-2-azido-2-deoxy-α-D-glucopyranoside 
• 100-39-0 benzyl bromide 
• 1401413-68-0 C₂₇H₂₉N₃O₆ 

Downstream Products

• 1401413-71-5 C₃₇H₃₈Cl₃NO₈ 
• 1401413-11-3 C₃₈H₃₆Cl₃F₃N₂O₇ 

Relevant academic research and scientific papers

Regioselective benzylation of 2-deoxy-2-aminosugars using crown ethers: Application to a shortened synthesis of hyaluronic acid oligomers

The combination of benzyl bromide, sodium hydroxide and 15-crown-5 in tetrahydrofuran is shown to be an efficient method for installing benzyl groups at both the 4- and 6-positions regioselectively directly from peracetylated N-trichloroacetyl-protected glucosamine and galactosamine. Application of this benzylation strategy proved to significantly shorten the synthetic route to hyaluronic acid tetra- and hexamers.

COMPOUNDS AND METHODS FOR CHEMICAL AND CHEMO-ENZYMATIC SYNTHESIS OF COMPLEX GLYCANS

The present invention provides chemical and chemo-enzymatic methods for the synthesis of a wide array of complex asymmetric multi-antennary glycans.