1401421-07-5Relevant academic research and scientific papers
Copper-Catalyzed Aerobic Annulation of Hydrazones: Direct Access to Cinnolines
Lan, Chunling,Tian, Zhuang,Liang, Xuchun,Gao, Mingchun,Liu, Wenting,An, Yu,Fu, Wencheng,Jiao, Guanming,Xiao, Junjie,Xu, Bin
, p. 3735 - 3740 (2017/10/07)
A novel method was developed for the construction of biologically active poly-substituted cinnolines from easily accessible hydrazones in good to excellent yields. A simple copper catalyst could efficiently promote C?N bond formation through selective C?H functionalization and dehydrogenative amination. Furthermore, the inert C?Heteroatom (O/F/N) bonds are susceptible to cleavage in high selectivity in the newly developed aerobic annulation, in preference to the alternative C?H bond, which is left intact. (Figure presented.).
Copper-catalyzed aerobic dehydrogenative cyclization of N-methyl-N-phenylhydrazones: Synthesis of cinnolines
Zhang, Guangwu,Miao, Jinmin,Zhao, Yan,Ge, Haibo
, p. 8318 - 8321 (2012/09/07)
O2 leading the way: The title reaction proceeds through an oxidation/cyclization sequence, thus representing the first copper-catalyzed coupling reaction of hydrazones through a C sp 3-H bond functionalization process (see scheme; DMF=N,N'-dimethylformamide, Py=pyridine). The method provides an environmentally friendly and atom-efficient approach to biologically active cinnoline derivatives. Copyright
