1401427-48-2Relevant articles and documents
Enantioselective synthesis of tertiary α-hydroxyketones from unfunctionalized ketones: Palladium-catalyzed asymmetric allylic alkylation of enolates
Trost, Barry M.,Koller, Raffael,Sch?ffner, Benjamin
supporting information; experimental part, p. 8290 - 8293 (2012/09/08)
Aiming high: The title reaction for the synthesis of tertiary α-hydroxyketones is reported. Protected 1,2-enediol carbonates, the starting materials, were accessed from simple and readily available enol carbonates. Highly functionalized tertiary α-hydroxyketones can be obtained in high yield with excellent enantioselectivity using this method (see scheme). Copyright