2749-70-4Relevant articles and documents
Metathesis reaction of formaldehyde acetals: An easy entry into the dynamic covalent chemistry of cyclophane formation
Cacciapaglia, Roberta,Di Stefano, Stefano,Mandolini, Luigi
, p. 13666 - 13671 (2005)
The acid-catalyzed transacetalation of formaldehyde acetals (formal metathesis) is a suitable reaction for the generation of well-behaved Dynamic Libraries of cyclophane formals. The composition of the equilibrated mixtures solely depends on concentration
Utilization of Formic Acid as C1 Building Block for the Ruthenium-Catalyzed Synthesis of Formaldehyde Surrogates
Beydoun, Kassem,Thenert, Katharina,Wiesenthal, Jan,Hoppe, Corinna,Klankermayer, Jürgen
, p. 1944 - 1947 (2020/04/08)
Dialkoxymethanes are becoming increasingly important as fuel additives, formaldehyde surrogates, and chemical intermediates, but the effective synthesis remains challenging. Herein, the catalytic synthesis of dialkoxymethane products using a molecular catalyst is reported. The catalytic system, comprising the [Ru(triphos)(tmm)] in combination with the Lewis acid Al(OTf)3, enables the direct synthesis of dialkoxymethane products with formic acid as C1 building block in high to excellent turnover numbers.
Nickel-catalyzed direct synthesis of dialkoxymethane ethers
Subaramanian, Murugan,Bera, Abhijit,Prasad, Bhagavatula L V,Balaraman, Ekambaram
, p. 1153 - 1159 (2017/08/26)
221A simple and efficient method for the preparation of dialkoxymethane ethers (oxymethylene ethers) from alcohols and paraformaldehyde in the presence of commercially available nickel(II) salt is described. The reaction proceeds readily under neutral, solvent-free conditions using paraformaldehyde as a C 1 source. The present strategy has a broad substrate scope including aliphatic (both primary and secondary) and aromatic alcohols and provides a benign method for the preparation of symmetrical dialkoxymethanes in good yields (up to 89%). Graphical Abstract: SYNOPSIS A facile nickel-catalyzed synthesis of dialkoxymethane ethers from alcohols and paraformaldehyde using inexpensive, commercially available NiBr 2 is reported. The reaction proceeds readily under mild, neutral and solvent-free conditions. [Figure not available: see fulltext.].