1401427-97-1

Usage

Uses

Used in Biomedical Research:
DASPMI is used as a fluorescent dye for various applications in biomedical research, such as in vivo cell imaging, protein labeling, and DNA/RNA detection. Its high fluorescence intensity and photo stability make it a reliable choice for these purposes.
Used in Photodynamic Therapy:
DASPMI is also being studied for its potential as a photosensitizer in photodynamic therapy for cancer treatment. Its properties may contribute to the development of new therapeutic approaches in oncology.
Used in Diagnostic Applications:
(E)-2-(4-(dimethylamino) styryl)-4H-chromen-4-one's fluorescence characteristics make it suitable for use in diagnostic applications, where its ability to label and detect specific biological molecules can aid in the identification and analysis of various conditions.
Used in Chemical Research:
In the field of chemical research, DASPMI serves as a valuable tool for studying molecular interactions and investigating the properties of different chemical compounds. Its unique structure and fluorescence properties facilitate the exploration of new chemical reactions and mechanisms.

Upstream product

• 5751-48-4 2-methylchromone 
• 100-10-7 4-dimethylamino-benzaldehyde 
• 15058-15-8 2-(2-methyl-4H-1-benzopyran-4-ylidene)propanedinitrile 

Relevant academic research and scientific papers

A Solvatochromic Fluorescent Probe Reveals Polarity Heterogeneity upon Protein Aggregation in Cells

We report a crystallization-induced emission fluorophore to quantitatively interrogate the polarity of aggregated proteins. This solvatochromic probe, namely “AggRetina” probe, inherently binds to aggregated proteins and exhibits both a polarity-dependent fluorescence emission wavelength shift and a viscosity-dependent fluorescence intensity increase. Regulation of its polarity sensitivity was achieved by extending the conjugation length. Different proteins bear diverse polarity upon aggregation, leading to different resistance to proteolysis. Polarity primarily decreases during protein misfolding but viscosity mainly increases upon the formation of insoluble aggregates. We quantified the polarity of aggregated protein-of-interest in live cells via HaloTag bioorthogonal labeling, revealing polarity heterogeneity within cellular aggregates. The enriched micro-environment details inside misfolded and aggregated proteins may correlate to their bio-chemical properties and pathogenicity.

Rational design of novel near-infrared fluorescent DCM derivatives and their application in bioimaging

The development of innovative strategies for high-performance near-infrared (NIR) fluorescent materials is in urgent demand for bioimaging. By replacing the stronger electron-withdrawing groups or extending the π-conjugated system, novel NIR fluorescent materials of DCM analogues have been developed, along with several striking characteristics: bright NIR fluorescence over 700 nm, large Stokes shift and good photo-stability. It is demonstrated that introducing a stronger electron-withdrawing unit to the acceptor moiety of DCM analogues is a favourably efficient strategy to tune and prolong the emission wavelength into the NIR region with a large Stokes shift. In comparison with the commercial NIR dye ICG, S-DCM-N and S-DCM-P display excellent photostability and low photobleaching. The large Stokes Shift and NIR fluorescence channel of S-DCM-N and S-DCM-P are very favourable for fluorescence labelling with a high signal-to-noise ratio in living species.

Structure-activity relationship study of growth inhibitory 2-styrylchromones against carcinoma cells

The structure-activity relationship study of 2-styrylchromones against carcinoma cell growth is discussed in the present report. Taking advantage of 2-styrylchromone as a molecular template, a series of structural modifications was carried out and examined on several carcinoma cell lines. Interestingly, AGS cells exhibited more sensitivity in response to methoxy-bearing compounds, of which compound 23 (3,4,5-trimethoxy group on ring B) showed the most potent activity with a GI50 value of 1.3 μM. Surprisingly, as methoxy groups in 12 and 24-27 were demethylated to generate their hydroxyl counterparts 28-32, none of them displayed appreciable activity against all carcinoma cells. We further confirmed the pivotal role of rigidity for growth inhibitory activity between the rigid 12 and its flexible counterpart 33. Taken together, in the present report, we have clearly demonstrated the structure-activity relationship study of 2-styrylchromones targeting carcinoma cell growth.