1401467-75-1Relevant articles and documents
Enantioselective thiourea-catalyzed intramolecular cope-type hydroamination
Brown, Adam R.,Uyeda, Christopher,Brotherton, Carolyn A.,Jacobsen, Eric N.
, p. 6747 - 6749 (2013/06/05)
Catalysis of Cope-type rearrangements of bis-homoallylic hydroxylamines is demonstrated using chiral thiourea derivatives. This formal intramolecular hydroamination reaction provides access to highly enantioenriched α-substituted pyrrolidine products and represents a complementary approach to metal-catalyzed methods.