764650-92-2

Upstream product

• 20439-47-8 (1R,2R)-1,2-diaminocyclohexane 
• 583-05-1 1-phenylpentane-1,4-dione 

Downstream Products

• 1195974-32-3 1-(2-((S)-3,3-dimethyl-2-(3-((1R,2R)-2-(2-methyl-5-phenyl-1H-pyrrol-1-yl)cyclohexyl)thioureido)butoxy)-5-(trifluoromethyl)phenyl)-3-ethylurea 
• 1195974-37-8 1-(2-((S)-3,3-dimethyl-2-(3-((1R,2R)-2-(2-methyl-5-phenyl-1H-pyrrol-1-yl)cyclohexyl)ureido)butoxy)-5-(trifluoromethyl)phenyl)-3-ethylurea 
• 1195974-42-5 1-((S)-3,3-dimethyl-1-(4-(trifluoromethyl)phenoxy)butan-2-yl)-3-((1R,2R)-2-(2-methyl-5-phenyl-1H-pyrrol-1-yl)cyclohexyl)thiourea 
• 1431561-58-8 1-((S)-3,3-dimethyl-1-oxo-1-((R)-2-(pyren-4-yl)pyrrolidin-1-yl)butan-2-yl)-3-((1R,2R)-2-(2-methyl-5-phenyl-1H-pyrrol-1-yl)cyclohexyl)thiourea 
• 1401467-75-1 1-((S)-3,3-dimethyl-1-oxo-1-((R)-2-(phenanthren-9-yl)pyrrolidin-1-yl)butan-2-yl)-3-((1R,2R)-2-(2-methyl-5-phenyl-1H-pyrrol-1-yl)cyclohexyl)thiourea 
• 1431561-56-6 1-((S)-3,3-dimethyl-1-oxo-1-((R)-2-phenylpyrrolidin-1-yl)butan-2-yl)-3-((1R,2R)-2-(2-methyl-5-phenyl-1H-pyrrol-1-yl)cyclohexyl)thiourea 
• 959979-72-7 (S)-N-benzhydryl-N,3,3-trimethyl-2-(3-((1R,2R)-2-(2-methyl-5-phenyl-1H-pyrrol-1-yl)cyclohexyl)thioureido)butanamide 
• 764650-97-7 (S,R,R)-N,N-diisobutyl-3,3-dimethyl-2-{3-[2-(2-methyl-5-phenyl-pyrrol-1-yl)-cyclohexyl]-thioureido}-butyramide 

Relevant academic research and scientific papers

Enantioselective total synthesis of (+)-arborescidine C and related tetracyclic indole alkaloids using organocatalysis

A concise and enantioselective synthesis of the tetracyclic indoles, including the naturally occurring compounds (+)-arborescidine C and (+)-arborescidine B, was achieved by the key step of Pictet-Spengler cyclization reaction with a Jacobsen-type thiourea organocatalyst. The synthetic process was further demonstrated in a pot-economy strategy and was achieved in a one-pot operation.

Regio-and enantioselective catalytic cyclization of pyrroles onto N-acyliminium lons

The regio- and enantioselective cyclization of pyrroles onto N-acyliminium ions generated in situ from hydroxylactams is reported. Modest to excellent ee's and yields are obtained in these novel Pictet-Spengler-type reactions with a chiral thiourea-pyrrole catalyst. Useful synthetic transformations of the versatile pyrroloindolizidinone and pyrroloquinolizidinone products are presented.

Organocatalytic asymmetric transfer hydrogenation of nitroolefins

We describe a highly efficient and highly enantioselective Hantzsch ester mediated conjugate transfer hydrogenation of β,β-disubstituted nitroolefins that is catalyzed by a Jacobsen-type thiourea catalyst. Copyright

Enantioselective Pictet-Spengler-type cyclizations of hydroxylactams: H-bond donor catalysis by anion binding

Highly enantioenriched indolizinone and quinolizinone products are obtained in the thiourea-catalyzed cyclization of tryptamine-derived hydroxylactams. Substituent and counterion effect studies point to a novel mechanism of catalysis involving rate-limiti

Enantioselective thiourea-catalyzed acyl-Mannich reactions of isoquinolines

(Chemical Equation Presented) Inexpensive aromatic feedstocks are substrates for highly enantioselective acylative Mannich reactions catalyzed by a thiourea chiral hydrogen-bond donor 1. This methodology provides access to useful 1-substituted dihydroisoq

Highly enantioselective catalytic acyl-Pictet-Spengler reactions

The enantioselective cyclization of N-acyliminium ions generated in situ from tryptamine is promoted with high enantioselectivity by a new chiral thiourea catalyst. This represents the first successful system for asymmetric catalysis of the Pictet-Spengle