140147-36-0 Usage
Uses
Used in Diagnostic Applications:
n-Octyl 3,6-Di-O-(a-D-mannopyranosyl)-b-D-mannopyranoside is used as an acceptor in the assay of N-Acetylglucosaminyltransferase-1, which is an essential enzyme involved in the biosynthesis of various glycoconjugates. n-Octyl 3,6-Di-O-(a-D-mannopyranosyl)-b-D-mannopyranoside serves as a valuable diagnostic tool for identifying autosomal recessive congenital muscular dystrophies, a group of genetic disorders characterized by progressive muscle weakness and degeneration. These dystrophies can also have associated brain and eye abnormalities, making the accurate diagnosis of n-Octyl 3,6-Di-O-(a-D-mannopyranosyl)-b-D-mannopyranoside crucial for appropriate patient management and treatment.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, n-Octyl 3,6-Di-O-(a-D-mannopyranosyl)-b-D-mannopyranoside is used as a key component in the development of novel drug delivery systems. Its unique structural properties allow for the targeted delivery of therapeutic agents to specific cells or tissues, potentially improving the efficacy and reducing the side effects of various treatments. Additionally, its role in the assay of N-Acetylglucosaminyltransferase-1 makes it a valuable tool in the research and development of new drugs targeting this enzyme for the treatment of various diseases, including muscular dystrophies and other glycosylation-related disorders.
Used in Research and Development:
n-Octyl 3,6-Di-O-(a-D-mannopyranosyl)-b-D-mannopyranoside is also utilized in research and development settings, particularly in the fields of biochemistry, cell biology, and molecular biology. Its unique structure and function make it an important tool for studying the role of glycosylation in various biological processes, such as cell adhesion, cell signaling, and protein folding. Furthermore, its use in the assay of N-Acetylglucosaminyltransferase-1 contributes to the understanding of the enzyme's function and its potential as a therapeutic target for various diseases.
Check Digit Verification of cas no
The CAS Registry Mumber 140147-36-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,4,0,1,4 and 7 respectively; the second part has 2 digits, 3 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 140147-36:
(8*1)+(7*4)+(6*0)+(5*1)+(4*4)+(3*7)+(2*3)+(1*6)=90
90 % 10 = 0
So 140147-36-0 is a valid CAS Registry Number.
InChI:InChI=1/C26H48O16/c1-2-3-4-5-6-7-8-37-25-22(36)23(42-26-21(35)19(33)16(30)13(10-28)40-26)17(31)14(41-25)11-38-24-20(34)18(32)15(29)12(9-27)39-24/h12-36H,2-11H2,1H3
140147-36-0Relevant articles and documents
4,6-Di-O-benzoyl-3-O-benzyl-α-D-arabino-hexo-pyranos-2-ulosyl bromide: A conveniently accessible glycosyl donor for the expedient construction of diantennary β-D-mannosides branched at O-3 and O-6
Lichtenthaler, Frieder W.,Klaeres, Ulrich,Szurmai, Zoltan,Werner, Bernd
, p. 293 - 303 (1997)
A concise practical, large scale-adaptable six-step sequence has been developed for the transformation of diacetone-glucose into 4,6-di-O-benzoyl- 3-O-benzyl-α-D-arabino-hexo-pyranos-2-ulosyl bromide (7), a most useful indirect β-D-mannosyl donor as its blocking group pattern allows the construction of biologically relevant β-D-mannosides branched at O-3 and O- 6. The broad utility of this new ulosyl bromide 7 resides in its high anomeric reactivity, and in the ease and uniformity with which β- stereocontrol can be achieved over both, glycosidations and carbonyl reduction of the β-ulosides formed: Koenigs-Knorr conditions exclusively provide β-glycosiduloses, hydride reduction of their carbonyl functions proceeds with high stereoselectivities (> 20:1) in favor of the β-D- mannosides. These preparatively auspicious properties are materialized in an efficient, straightforward synthesis of α-D-Manp-(1 → 6)-[α-D-Manp-(1 → 3)]-β-D-Manp-(1 → O)-Octyl, the 3,6-O-branched core-mannotrioside carrying an octyl spacer instead of the chitobiosyl unit.
