1401513-99-2Relevant academic research and scientific papers
5-Nitro-heteroarylidene analogs of 2-thiazolylimino-4-thiazolidinones as a novel series of antibacterial agents
Hosseinzadeh, Nouraddin,Hasani, Mohammad,Foroumadi, Alireza,Nadri, Hamid,Emami, Saeed,Samadi, Nasrin,Faramarzi, Mohammad Ali,Saniee, Parastoo,Siavoshi, Farideh,Abadian, Neda,Mahmoudjanlou, Yasaman,Sakhteman, Amirhossein,Moradi, Alireza,Shafiee, Abbas
, p. 2293 - 2302 (2013/07/26)
In the pursuit of novel antibacterial agents with the 2-thiazolylimino-4- thiazolidinone as a core structure, a series of 5-nitro-heteroarylidene and 5-(2-oxoindolin-3-ylidene) analogs of 2-thiazolylimino-5-arylidene-4- thiazolidinone were synthesized and their antibacterial activities were evaluated against some strains of Gram-positive and Gram-negative bacteria, as well as Helicobacter pylori strains. Biological data indicated that 5-nitrofuran analog 5a and 5-nitroimidazole analog 7a containing no substitutions on the thiazole ring were the most potent compounds.
