1401518-67-9

Basic information

• Product Name: 2-benzyl-1-(pyridin-2-yl)-1H-indole
• Synonyms: 2-benzyl-1-(pyridin-2-yl)-1H-indole
• CAS NO: 1401518-67-9
• Molecular Weight: 284.36
• Mol File: 1401518-67-9.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 2-benzyl-1-(pyridin-2-yl)-1H-indole(CAS DataBase Reference)
• NIST Chemistry Reference: 2-benzyl-1-(pyridin-2-yl)-1H-indole(1401518-67-9)
• EPA Substance Registry System: 2-benzyl-1-(pyridin-2-yl)-1H-indole(1401518-67-9)

Safety Data

• Hazardous Substances Data: 1401518-67-9(Hazardous Substances Data)

Upstream product

• 108-88-3 toluene 
• 3419-91-8 N-(2-pyridyl)indole 
• 884-90-2 benzyl diethyl phosphate 

Relevant articles and documents

Nickel-Catalyzed C(sp2)-H/C(sp3)-H Oxidative Coupling of Indoles with Toluene Derivatives

Nickel-catalyzed oxidative C(sp2)-H/C(sp3)-H coupling of indoles with toluene derivatives is successfully achieved in the presence of 2-iodobutane as the oxidant. This method allows the selective C-2 benzylation of indoles with toluene derivatives over the alkylation with 2-iodobutane and permits the coupling of diversified indoles via the monochelation assistance. The reaction proceeded through a single-electron-transfer (SET) process, wherein both the C-H nickelation of indole and the C-H activation of toluene derivatives have a significant effect on the entire reaction rate. The synthetic utility of this nickel-catalyzed protocol is demonstrated by the facile removal of the directing group and by the convenient synthesis of the melatonin receptor antagonist Luzindole derivatives.

Cobalt-catalyzed direct arylation and benzylation by C-H/C-O cleavage with sulfamates, carbamates, and phosphates

Inexpensive cobalt catalysts enable the first direct arylation and benzylation of (hetero)arenes with aryl carbamates, sulfamates, and phosphates with ample scope. The non-radical C-H/C-O arylation reaction even proved viable at ambient temperature. Copyr