1401522-37-9

Basic information

• Product Name: 4-{[1-hydroxy-3-oxo-1-(phenoxymethyl)isoindol-2-yl]methyl}phenyl acetate
• Synonyms: 4-{[1-hydroxy-3-oxo-1-(phenoxymethyl)isoindol-2-yl]methyl}phenyl acetate
• CAS NO: 1401522-37-9
• Molecular Weight: 403.434
• Mol File: 1401522-37-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 4-{[1-hydroxy-3-oxo-1-(phenoxymethyl)isoindol-2-yl]methyl}phenyl acetate(CAS DataBase Reference)
• NIST Chemistry Reference: 4-{[1-hydroxy-3-oxo-1-(phenoxymethyl)isoindol-2-yl]methyl}phenyl acetate(1401522-37-9)
• EPA Substance Registry System: 4-{[1-hydroxy-3-oxo-1-(phenoxymethyl)isoindol-2-yl]methyl}phenyl acetate(1401522-37-9)

Safety Data

• Hazardous Substances Data: 1401522-37-9(Hazardous Substances Data)

Upstream product

• 58613-67-5 potassium phenoxyacetate 
• 630393-48-5 2-(4-acetoxybenzyl) isoindoline-1,3-dione 

Downstream Products

• 1401522-54-0 (E)-2-(4-hydroxybenzyl)-3-(phenoxymethylene)isoindolin-1-one 
• 1401522-56-2 (Z)-2-(4-hydroxybenzyl)-3-(phenoxymethylene)isoindolin-1-one 

Relevant articles and documents

Photodecarboxylative addition of carboxylates to phthalimides: A concise access to biologically active 3-(alkyl and aryl)methylene-1H-isoindolin-1-ones

A series of 3-(alkyl and aryl)methyleneisoindolin-1-one derivatives were synthesized in a simple two-step procedure using a recently established photodecarboxylative addition of carboxylates to phthalimides as the key-step. Subsequent acid-catalyzed dehydration and deprotection furnished the desired target compounds with high E-selectivity. The reaction sequence was applied to the synthesis of the known bioactive phenylethylene derivative, AKS-186. Different analogues, including heteroatom-containing isosteres were also synthesized using this approach.