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Upstream product

• 613-91-2 acetophenone oxime 
• 35843-79-9 (6-chloro-1-hexyn-1-yl)benzene 
• 32366-25-9 1-azidoethylbenzene 
• 13280-20-1 1-phenylethanimine 

Relevant academic research and scientific papers

C-H activation guided by aromatic N-H ketimines: Synthesis of functionalized isoquinolines using benzyl azides and alkynes

Aromatic N-H ketimines were in situ generated from various benzylic azides by ruthenium catalysis for the subsequent Rh-catalyzed annulation reaction with alkynes to give the corresponding isoquinolines. In contrast to conventional synthetic methods for aromatic N-H ketimines, our protocol works under mild and neutral conditions, which enabled the synthesis of isoquinolines having various functionalities such as carbonyl, ester, alkenyl, and ether groups. In addition, the imidates generated from α-azido ethers were successfully used for the synthesis of 1-alkoxyisoquinolines.

Cationic ruthenium catalysts for alkyne annulations with oximes by C-H/N-O functionalizations

Cationic ruthenium(II) complexes enabled efficient redox-neutral annulations of alkynes with readily available oximes. The catalytic dehydrative C-H/N-O bond functionalization proved to be broadly applicable and was shown to proceed through a reversible cyclometalation.