1401560-64-2Relevant academic research and scientific papers
Palladium(II)-catalyzed tandem cyclization/C-H functionalization of alkynes for the synthesis of functionalized indoles
Xia, Xiao-Feng,Wang, Ning,Zhang, Lu-Lu,Song, Xian-Rong,Liu, Xue-Yuan,Liang, Yong-Min
, p. 9163 - 9170 (2013/01/15)
A palladium-catalyzed tandem cyclization/C-H functionalization of two alkynes was accomplished to construct a series of polycyclic functionalized indoles. A range of internal alkynes bearing synthetically useful functional groups were tolerated. A good regioselectivity was observed when alkyl-substituted alkynes were introduced into the reaction system, and a single product was obtained. Molecular oxygen was used as the terminal oxidant in the approach, rendering the reaction more sustainable.
