1401616-03-2Relevant academic research and scientific papers
Synthesis method of 2-aroyl quinoline derivative
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Paragraph 0015, (2021/11/19)
The invention relates to a synthesis method of a 2-aroyl quinoline derivative, which comprises the following steps: by taking 2-bromoaniline and aryl cyclobutanol as reaction substrates, palladium chloride as a catalyst, tricyclohexylphosphine as a ligand, cesium carbonate as alkali and ultra-dry toluene as a solvent, stirring and reacting for 12 hours under the protection of nitrogen at 110 DEG C, then taking tetrabutylammonium iodide as a phase transfer catalyst, under the conditions of acetic acid and potassium persulfate, stirring and reacting for 16 hours at 90 DEG C by taking methylbenzene as a solvent; the method has the advantages of relatively low requirements on reaction conditions, mild conditions, simple operation steps, simple and easily available raw materials, great reduction of environmental pollution and the like.
A general access to 1,1-cyclopropane aminoketones and their conversion into 2-benzoyl quinolines
Mao, Zhenjun,Qu, Haijun,Zhao, Yanyan,Lin, Xufeng
supporting information, p. 9927 - 9929 (2012/11/06)
1,1-Cyclopropane aminoketones were efficiently synthesized in high yields by the tandem reaction of α-amino aryl ketones with vinyl sulfonium salts using DBU as the base in CH2Cl2. This methodology was utilized to synthesize 2-benzoyl quinolines. The Royal Society of Chemistry 2012.
