252931-59-2

Upstream product

• 108-42-9 3-chloro-aniline 
• 70-11-1 α-bromoacetophenone 

Downstream Products

• 66354-66-3 4-chloro-2-phenyl-1H-indole 
• 127791-92-8 ethyl 1-(3-chlorophenyl)-2-<2-(benzyloxy)phenyl>-4-phenylpyrrole-3-carboxylate 
• 57039-63-1 6-chloro-2-phenylindole 
• 1401615-89-1 (1-(3-chlorophenylamino)cyclopropyl)(phenyl)methanone 
• 1401616-03-2 (7-chloroquinolin-2-yl)(phenyl)methanone 
• 1401616-04-3 (5-chloroquinolin-2-yl)(phenyl)methanone 
• 127792-00-1 1-(3-chlorophenyl)-2-<2-(benzyloxy)phenyl>-4-phenylpyrrole-3-carboxylic acid 
• 127792-07-8 1-(3-chlorophenyl)-2-(2-hydroxyphenyl)-4-phenylpyrrole-3-carboxylic acid 
• 127791-83-7 1,4-dihydro-1-(3-chlorophenyl)-3-phenyl<1>benzopyrano<4,3-b>pyrrol-4-one 

Relevant academic research and scientific papers

New efficient synthesis of 1,4-benzodiazepin-5-ones by catalytic aza-Wittig reaction

1,4-Benzodiazepin-5-ones were synthesized in 71-89% yields from 2-isocyanato-N-(2-oxoalkyl)benzamides via a new catalytic intramolecular aza-Wittig reaction. Starting from easily accessible phthalic anhydride and α-arylamino ketones, the corresponding 2-{[(2-oxoalkyl)amino]carbonyl}benzoic acids underwent sequential formation of the acid azide and Curtis rearrangement to give 2-isocyanato-N-(2-oxoalkyl)benzamides that were reacted directly to give the final 2,4-diaryl-3,4-dihydro-5H-1,4-benzodiazepin-5-ones and 4-aryl-2-tert-butyl-3,4-dihydro-5H-1,4-benzodiazepin-5-ones.

Regioselective Synthesis of 2-Arylindoles via Palladium-Catalyzed Cyclization of Phenylglyoxal and 2-Anilinoacetophenones with Anilines

A versatile route has been developed for the synthesis of 2-arylindoles using a Pd-catalyzed tandem process. Under reductive conditions, different 2-arylindoles were synthesized from phenylglyoxal and aniline. This synthetic methodology involves a tandem reaction of four steps with high regioselectivity. Alternatively, 2-anilinoacetophenones intermediates also can be using to give access to the corresponding 2-arylindoles.

Iodine monobromide catalysed regioselective synthesis of 3-arylquinolines from α-aminoacetophenones and: Trans -β-nitrostyrenes

A simple and efficient method for regioselective synthesis of 3-arylquinolines is described from α-aminoacetophenones and trans-β-nitrostyrenes using 20 mol% iodine monobromide as a catalyst in acetonitrile solvent at 80 °C. The present method involves tandem reaction of α-aminoacetophenones and trans-β-nitrostyrenes, formation of two new C-C bonds and cleavage of one C-C bond in a single step. The salient features of the protocol are metal- and oxidant-free reaction conditions, broad substrate scope, and good yields.