1401616-05-4Relevant academic research and scientific papers
Acyl Radicals from Terminal Alkynes: Photoredox-Catalyzed Acylation of Heteroarenes
Sultan, Shaista,Rizvi, Masood Ahmad,Kumar, Jaswant,Shah, Bhahwal Ali
supporting information, p. 10617 - 10620 (2018/07/31)
A photoredox-mediated acylation reaction of electron deficient heteroarenes with terminal alkynes is reported. The method relies on oxidative cleavage of phenylacetylenes for generation of acyl radicals as a key enabling feature. The reaction is regiosele
I2-Promoted Povarov-Type Reaction Using 1,4-Dithane-2,5-diol as an Ethylene Surrogate: Formal [4 + 2] Synthesis of Quinolines
Wu, Xia,Geng, Xiao,Zhao, Peng,Zhang, Jingjing,Gong, Xingxing,Wu, Yan-Dong,Wu, An-Xin
supporting information, p. 1550 - 1553 (2017/04/13)
A highly efficient I2-promoted formal [4 + 2] cycloaddition has been developed for the synthesis of 2-acylquinolines from methyl ketones and arylamines using 1,4-dithane-2,5-diol as an ethylene surrogate. Moreover, the investigation of the mechanism suggested that this reaction occurred via an iodination/Kornblum oxidation/Povarov/aromatization sequence. It is noteworthy that the arylamine substrate also played an important role in promoting the reaction.
A general access to 1,1-cyclopropane aminoketones and their conversion into 2-benzoyl quinolines
Mao, Zhenjun,Qu, Haijun,Zhao, Yanyan,Lin, Xufeng
supporting information, p. 9927 - 9929 (2012/11/06)
1,1-Cyclopropane aminoketones were efficiently synthesized in high yields by the tandem reaction of α-amino aryl ketones with vinyl sulfonium salts using DBU as the base in CH2Cl2. This methodology was utilized to synthesize 2-benzoyl quinolines. The Royal Society of Chemistry 2012.
