1401623-58-2Relevant academic research and scientific papers
Enantioselective Michael addition of 3-aryloxindoles to a vinyl bisphosphonate ester catalyzed by a cinchona alkaloid derived thiourea catalyst
Zhao, Mei-Xin,Dai, Tong-Lei,Liu, Ran,Wei, Deng-Ke,Zhou, Hao,Ji, Fei-Hu,Shi, Min
supporting information, p. 7970 - 7979 (2013/06/27)
A highly enantioselective Michael addition of 3-aryloxindole to vinyl bisphosphonate ester catalyzed by a cinchonidine derived thiourea catalyst has been investigated. The corresponding adducts, containing a chiral quaternary carbon center and geminal bisphosphonate ester fragment at the 3-position of the oxindole, were obtained in moderate to good yields (65-92%) and moderate to good enantioselectivities (up to 92% ee).
