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Imidazo[1,2-a]pyridine-3-carbonitrile, 2-(4-methylphenyl)- is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

140166-78-5

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140166-78-5 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 140166-78-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,4,0,1,6 and 6 respectively; the second part has 2 digits, 7 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 140166-78:
(8*1)+(7*4)+(6*0)+(5*1)+(4*6)+(3*6)+(2*7)+(1*8)=105
105 % 10 = 5
So 140166-78-5 is a valid CAS Registry Number.

140166-78-5Downstream Products

140166-78-5Relevant articles and documents

Design, synthesis, and biological evaluation of chalcone-linked thiazole-imidazopyridine derivatives as anticancer agents

Suma, Vellanki Ragha,Sreenivasulu, Reddymasu,Rao, Mandava Venkata Basaveswara,Subramanyam, Madala,Ahsan, Mohamed Jawed,Alluri, Ramesh,Rao, Kuppili Ram Mohan

, p. 1643 - 1654 (2020)

A novel library of chalcone linked thiazole-imidazopyridine (12a–j) derivatives were designed, synthesized, and their structures were characterized by 1H NMR, 13C NMR and mass spectral studies. Further, all compounds were tested for their anticancer effects on four human cancer cell lines including MCF-7 (breast carcinoma), A549 (lung carcinoma), DU-145 (prostate carcinoma) and MDA MB-231 (breast carcinoma) by employing MTT method, using etoposide as the positive control. Among them, compound 12b displayed more potent anticancer activity against four cancer cell lines when compared to the positive control.

Copper- A nd DMF-mediated switchable oxidative C-H cyanation and formylation of imidazo[1,2-: A] pyridines using ammonium iodide

Ji, Fanghua,Jiang, Guangbin,Li, Xuan,Liu, Meichen,Wang, Shoucai,Zang, Jiawang

, p. 9100 - 9108 (2020/11/27)

The cyanation and formylation of imidazo[1,2-a]pyridines were developed under copper-mediated oxidative conditions using ammonium iodide and DMF as a nontoxic combined cyano-group source and DMF as a formylation reagent. Mechanistic studies indicate that the cyanation of imidazo[1,2-a]pyridines proceeds through a two-step sequence: Initial iodination and then cyanation. The cyanation has a broad substrate scope and high functional group tolerance, and can be safely conducted on a gram scale. A novel copper-mediated formylation using the widely available DMF as the formylation reagent and environmentally friendly molecular oxygen as the oxidant has also been developed. This protocol also provided a convenient approach for the synthesis of clinically used saripidem. This journal is

Construction of substituted 2-phenylimidazo[1,2-a]pyridine-3-nitrile by using DMF and ammonium iodide as cyanation reagents

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Paragraph 0064; 0065, (2019/12/02)

The invention discloses a novel method for one-step construction of substituted2-phenylimidazo[1,2-a]pyridine-3-nitrile by taking DMF (N,N-dimethylformamide) and ammonium iodide as cyanation reagents.According to the method, substituted 2-phenylimidazo[1,

ANGIOTENSIN II ANTAGONIZING HETEROCYCLIC DERIVATIVES

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, (2008/06/13)

The invention relates to compounds of the formula STR1 wherein STR2 represents a condensed or uncondensed imidazolyl ring and the rest of the variables are as defined in the specification. They are angiotensin II antagonists useful for treating hypertension, etc..

Substituted azoles, a process for their preparation, and their use

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, (2008/06/13)

The invention relates to compounds of the formula (I) STR1 in which X, Y and Z are identical or different and are N or CR2, and the other radicals have the meaning defined in the description, a process for the preparation thereof, agents contai

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