1401688-55-8

Basic information

• Product Name: C₂₂H₂₀F₃N₃O₃S
• Synonyms: C₂₂H₂₀F₃N₃O₃S
• CAS NO: 1401688-55-8
• Molecular Weight: 463.48
• Mol File: 1401688-55-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₂₂H₂₀F₃N₃O₃S(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₂H₂₀F₃N₃O₃S(1401688-55-8)
• EPA Substance Registry System: C₂₂H₂₀F₃N₃O₃S(1401688-55-8)

Safety Data

• Hazardous Substances Data: 1401688-55-8(Hazardous Substances Data)

Upstream product

• 344-25-2 D-Prolin 
• 18704-37-5 quinoline-8-sulfonyl chloride 
• 87650-63-3 (S)-1-(quinolin-8-ylsulfonyl)pyrrolidine-2-carboxylic acid 
• 25449-96-1 3-amino-4-methylbenzotrifluoride 

Relevant articles and documents

(S)- N -(2,5-Dimethylphenyl)-1-(quinoline-8-ylsulfonyl)pyrrolidine-2- carboxamide as a small molecule inhibitor probe for the study of respiratory syncytial virus infection

A high-throughput, cell-based screen was used to identify chemotypes as inhibitors for human respiratory syncytial virus (hRSV). Optimization of a sulfonylpyrrolidine scaffold resulted in compound 5o that inhibited a virus-induced cytopathic effect in the entry stage of infection (EC50 = 2.3 ± 0.8 μM) with marginal cytotoxicity (CC50 = 30.9 ± 1.1 μM) and reduced viral titer by 100-fold. Compared to ribavirin, sulfonylpyrrolidine 5o demonstrated an improved in vitro potency and selectivity index.