1401696-32-9

Upstream product

• 1246513-40-5 5-(4-fluorophenyl)-1-(4-isopropylphenyl)-1H-pyrazol-3-ol 
• 572-09-8 2,3,4,6-tetra-O-acetyl-α-D-glucopyranosyl bromide 
• 3947-62-4 2,3,4,6-tetra-O-acetyl-β-D-glucopyranose 

Downstream Products

• 1401696-42-1 5-(4-fluorophenyl)-1-[4-(propan-2-yl)phenyl]-1H-pyrazol-3-yl β-D-glucopyranoside 

Relevant academic research and scientific papers

Crystal structures, vibrational spectra, and fungicidal activity of 1,5-diaryl-3-oxypyrazoles

The aryloxypyrazole structure is present in a number of bioactive molecules. Four 1,5-diaryl-3-oxypyrazoles containing benzoyl (I), thiazolidinethione (II and III) or per-O-Acetylated glucopyranosyl (IV) moieties were characterized by single-crystal X-ray

Synthesis, crystal structures, and fungicidal activity of novel 1,5-diaryl-3-(glucopyranosyloxy)-1H-pyrazoles

Five novel pyrazole-coupled glucosides, 1,5-diaryl-1H-pyrazol-3-yl 2,3,4,6-tetra-O-acetyl-β-D-glucopyranosides 5a-5e, were synthesized by the phase-transfer catalytic reaction of 1,5-diaryl-1H-pyrazol-3-ols 4a-4e with acetobromo-α-D-glucose in H2O/CHCl3 under alkaline conditions, using Bu4N+Br- as catalyst. Then, glucosides 5a-5c were deacetylated in a solution of Na2CO 3/MeOH to yield the 1,5-diaryl-3-(β-D-glucopyranosyloxy)-1H- pyrazoles 6a-6c. Their structures were characterized by 1H, 1H-COSY, 1H-, 13C-, and 19F-NMR spectroscopy, as well as elemental analysis. The structures of 5d and 6c were also determined by single-crystal X-ray diffraction analysis. A preliminary in vitro bioassay indicated that compounds 4e and 5d exhibited excellent-to-medium fungicidal activity against Sclerotinia sclerotiorum at the dosage of 10μg/ml.