1401699-49-7

Basic information

• Product Name: N-[(4-methoxyphenyl)(diphenyl)methyl]-2’-C-methylguanosine
• Synonyms: N-[(4-methoxyphenyl)(diphenyl)methyl]-2’-C-methylguanosine
• CAS NO: 1401699-49-7
• Molecular Weight: 569.617
• Mol File: 1401699-49-7.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: N-[(4-methoxyphenyl)(diphenyl)methyl]-2’-C-methylguanosine(CAS DataBase Reference)
• NIST Chemistry Reference: N-[(4-methoxyphenyl)(diphenyl)methyl]-2’-C-methylguanosine(1401699-49-7)
• EPA Substance Registry System: N-[(4-methoxyphenyl)(diphenyl)methyl]-2’-C-methylguanosine(1401699-49-7)

Safety Data

• Hazardous Substances Data: 1401699-49-7(Hazardous Substances Data)

Upstream product

• 374750-30-8 2'-C-methylguanosine 
• 10310-21-1 2-Amino-6-chloropurin 
• 1613590-26-3 C₅₂H₄₂ClN₅O₈ 
• 641571-44-0 (2R,3R,4R,5R)-2-(2-amino-6-chloro-9H-purin-9-yl)-5-(benzoyloxymethyl)-3-methyltetrahydrofuran-3,4-diyl dibenzoate 
• 15397-15-6 1,2,3,5-tetra-O-benzoyl-2-C-methyl-β-D-ribofuranose 
• 10310-21-1 2-amino-6-chloropurine 

Downstream Products

• 1613590-21-8 4'-fluoro-2'-C-methyl-N²-(methoxytrityl)guanosine 
• 1613590-20-7 4'-fluoro-2',3',5'-tri-O-benzoyl-2'-C-methyl-N²-(methoxytrityl)guanosine 
• 1613590-60-5 C₄₅H₃₇FIN₅O₇ 
• 1613590-59-2 C₃₁H₂₉FIN₅O₅ 

Relevant articles and documents

SUBSTITUTED NUCLEOSIDES, NUCLEOTIDES AND ANALOGS THEREOF

Disclosed herein are nucleosides, nucleotide analogs, methods of synthesizing nucleotide analogs and methods of treating diseases and/or conditions such as a Filoviridae virus infection with one or more nucleosides and/or nucleotide analogs.

Synthesis of 3',5'-cyclic phosphate and thiophosphate esters of 2'-C-methyl ribonucleosides

2'-C-Methylnucleosides are known to exhibit antiviral activity against Hepatitis C virus. Since the inhibitory activity depends on their intracellular conversion to 5'-triphosphates, dosing as appropriately protected 5'-phosphates or 5'-phosphorothioates appears attractive. For this purpose, four potential pro-drugs of 2'-C-methylguanosine, i.e., 3',5'-cyclic phosphorothioate of 2'-C-methylguanosine and 2'-C,O6-dimethylguanosine, 1 and 2, respectively, the S-[(pivaloyloxy)methyl] ester of 2'-C,O6- dimethylguanosine 3',5'-cyclic phosphorothioate and the O-methyl ester of 2'-C,O6-dimethylguanosine 3',5'-cyclic phosphate, 3 and 4, respectively, have been prepared.