1401728-34-4

Basic information

• Product Name: (E)-2-ethyl-5,7-dimethyl-3-(4-(3-(piperazin-1-yl)prop-1-enyl)benzyl)pyrazolo[1,5-a]pyrimidine
• Synonyms: (E)-2-ethyl-5,7-dimethyl-3-(4-(3-(piperazin-1-yl)prop-1-enyl)benzyl)pyrazolo[1,5-a]pyrimidine
• CAS NO: 1401728-34-4
• Molecular Weight: 389.544
• Mol File: 1401728-34-4.mol

Chemical Properties

• CAS DataBase Reference: (E)-2-ethyl-5,7-dimethyl-3-(4-(3-(piperazin-1-yl)prop-1-enyl)benzyl)pyrazolo[1,5-a]pyrimidine(CAS DataBase Reference)
• NIST Chemistry Reference: (E)-2-ethyl-5,7-dimethyl-3-(4-(3-(piperazin-1-yl)prop-1-enyl)benzyl)pyrazolo[1,5-a]pyrimidine(1401728-34-4)
• EPA Substance Registry System: (E)-2-ethyl-5,7-dimethyl-3-(4-(3-(piperazin-1-yl)prop-1-enyl)benzyl)pyrazolo[1,5-a]pyrimidine(1401728-34-4)

Safety Data

• Hazardous Substances Data: 1401728-34-4(Hazardous Substances Data)

Upstream product

• 1401728-65-1 (E)-3-(4-((2-ethyl-5,7-dimethylpyrazolo[1,5-a]pyrimidin-3-yl)methyl)phenyl)prop-2-en-1-ol 
• 1401728-64-0 (E)-3-[4-(2-ethyl-5,7-dimethylpyrazolo[1,5-a]pyrimidin-3-ylmethyl)phenyl]acrylic acid methyl ester 
• 1401728-62-8 4-(4-bromobenzyl)-5-ethyl-2H-pyrazol-3-ylamine 
• 1401728-61-7 2-(4-bromobenzyl)-3-oxopentanenitrile 
• 57775-08-3 3-(4-Bromo-phenyl)-propionitrile 

Downstream Products

• 1401729-00-7 C₃₃H₅₁N₅O₂Si 
• 1401729-19-8 (R)-3-(4-{(E)-3-[4-(2-ethyl-5,7-dimethylpyrazolo[1,5-a]pyrimidin-3-ylmethyl)phenyl]allyl}piperazin-1-yl)propane-1,2-diol 

Relevant articles and documents

Development of Selective, Orally Active GPR4 Antagonists with Modulatory Effects on Nociception, Inflammation, and Angiogenesis

A novel, selective, and efficacious GPR4 antagonist 13 was developed starting from lead compound 1a. While compound 1a showed promising efficacy in several disease models, its binding to a H3 receptor as well as a hERG channel prevented it from further development. Therefore, a new round of optimization addressing the key liabilities was performed and led to discovery of compound 13 with an improved profile. Compound 13 showed significant efficacy in the rat antigen induced arthritis as well as in the hyperalgesia and angiogenesis model at a well-tolerated dose of 30 mg/kg.

PYRAZOLO PYRIMIDINE DERIVATIVES

The present invention relates to pyrazolo pyrimidine derivatives, to methods of preparing these, to combinations and pharmaceutical composition comprising these, and to their use in the treatment of diseases and disorders which may for example involve autoimmune diseases, angiogenesis, pain, and/or inflammatory diseases.