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CAS

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1401728-40-2

3-(4-((2-ethyl-5,7-dimethylpyrazolo[1,5-a]pyrimidin-3-yl)methyl)phenyl)-1-(piperazin-1-yl)propan-1-one hydrochloride is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

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  • 3-(4-((2-ethyl-5,7-dimethylpyrazolo[1,5-a]pyrimidin-3-yl)methyl)phenyl)-1-(piperazin-1-yl)propan-1-one hydrochloride

    Cas No: 1401728-40-2

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  • 1401728-40-2 Structure

  • Basic information

    1. Product Name: 3-(4-((2-ethyl-5,7-dimethylpyrazolo[1,5-a]pyrimidin-3-yl)methyl)phenyl)-1-(piperazin-1-yl)propan-1-one hydrochloride
    2. Synonyms: 3-(4-((2-ethyl-5,7-dimethylpyrazolo[1,5-a]pyrimidin-3-yl)methyl)phenyl)-1-(piperazin-1-yl)propan-1-one hydrochloride
    3. CAS NO:1401728-40-2
    4. Molecular Formula:
    5. Molecular Weight: 442.004
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 1401728-40-2.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: N/A
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: 3-(4-((2-ethyl-5,7-dimethylpyrazolo[1,5-a]pyrimidin-3-yl)methyl)phenyl)-1-(piperazin-1-yl)propan-1-one hydrochloride(CAS DataBase Reference)
    10. NIST Chemistry Reference: 3-(4-((2-ethyl-5,7-dimethylpyrazolo[1,5-a]pyrimidin-3-yl)methyl)phenyl)-1-(piperazin-1-yl)propan-1-one hydrochloride(1401728-40-2)
    11. EPA Substance Registry System: 3-(4-((2-ethyl-5,7-dimethylpyrazolo[1,5-a]pyrimidin-3-yl)methyl)phenyl)-1-(piperazin-1-yl)propan-1-one hydrochloride(1401728-40-2)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 1401728-40-2(Hazardous Substances Data)

1401728-40-2 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 1401728-40-2 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,4,0,1,7,2 and 8 respectively; the second part has 2 digits, 4 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 1401728-40:
(9*1)+(8*4)+(7*0)+(6*1)+(5*7)+(4*2)+(3*8)+(2*4)+(1*0)=122
122 % 10 = 2
So 1401728-40-2 is a valid CAS Registry Number.

1401728-40-2Downstream Products

1401728-40-2Relevant articles and documents

Development of Selective, Orally Active GPR4 Antagonists with Modulatory Effects on Nociception, Inflammation, and Angiogenesis

Velcicky, Juraj,Miltz, Wolfgang,Oberhauser, Berndt,Orain, David,Vaupel, Andrea,Weigand, Klaus,Dawson King, Janet,Littlewood-Evans, Amanda,Nash, Mark,Feifel, Roland,Loetscher, Pius

, p. 3672 - 3683 (2017/05/17)

A novel, selective, and efficacious GPR4 antagonist 13 was developed starting from lead compound 1a. While compound 1a showed promising efficacy in several disease models, its binding to a H3 receptor as well as a hERG channel prevented it from further development. Therefore, a new round of optimization addressing the key liabilities was performed and led to discovery of compound 13 with an improved profile. Compound 13 showed significant efficacy in the rat antigen induced arthritis as well as in the hyperalgesia and angiogenesis model at a well-tolerated dose of 30 mg/kg.

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