Welcome to LookChem.com Sign In|Join Free

CAS

  • or

1401728-87-7

4-(2-ethyl-5,7-dimethylpyrazolo[1,5-a]pyrimidin-3-ylmethyl)benzoic acid methyl ester is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

1401728-87-7 Suppliers

Post Buying Request

Recommended suppliersmore

  • Product
  • FOB Price
  • Min.Order
  • Supply Ability
  • Supplier
  • Contact Supplier
  • 1401728-87-7 Structure

  • Basic information

    1. Product Name: 4-(2-ethyl-5,7-dimethylpyrazolo[1,5-a]pyrimidin-3-ylmethyl)benzoic acid methyl ester
    2. Synonyms: 4-(2-ethyl-5,7-dimethylpyrazolo[1,5-a]pyrimidin-3-ylmethyl)benzoic acid methyl ester
    3. CAS NO:1401728-87-7
    4. Molecular Formula:
    5. Molecular Weight: 323.395
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 1401728-87-7.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: N/A
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: 4-(2-ethyl-5,7-dimethylpyrazolo[1,5-a]pyrimidin-3-ylmethyl)benzoic acid methyl ester(CAS DataBase Reference)
    10. NIST Chemistry Reference: 4-(2-ethyl-5,7-dimethylpyrazolo[1,5-a]pyrimidin-3-ylmethyl)benzoic acid methyl ester(1401728-87-7)
    11. EPA Substance Registry System: 4-(2-ethyl-5,7-dimethylpyrazolo[1,5-a]pyrimidin-3-ylmethyl)benzoic acid methyl ester(1401728-87-7)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 1401728-87-7(Hazardous Substances Data)

1401728-87-7 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 1401728-87-7 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,4,0,1,7,2 and 8 respectively; the second part has 2 digits, 8 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 1401728-87:
(9*1)+(8*4)+(7*0)+(6*1)+(5*7)+(4*2)+(3*8)+(2*8)+(1*7)=137
137 % 10 = 7
So 1401728-87-7 is a valid CAS Registry Number.

1401728-87-7Relevant articles and documents

Development of Selective, Orally Active GPR4 Antagonists with Modulatory Effects on Nociception, Inflammation, and Angiogenesis

Velcicky, Juraj,Miltz, Wolfgang,Oberhauser, Berndt,Orain, David,Vaupel, Andrea,Weigand, Klaus,Dawson King, Janet,Littlewood-Evans, Amanda,Nash, Mark,Feifel, Roland,Loetscher, Pius

supporting information, p. 3672 - 3683 (2017/05/17)

A novel, selective, and efficacious GPR4 antagonist 13 was developed starting from lead compound 1a. While compound 1a showed promising efficacy in several disease models, its binding to a H3 receptor as well as a hERG channel prevented it from further development. Therefore, a new round of optimization addressing the key liabilities was performed and led to discovery of compound 13 with an improved profile. Compound 13 showed significant efficacy in the rat antigen induced arthritis as well as in the hyperalgesia and angiogenesis model at a well-tolerated dose of 30 mg/kg.

PYRAZOLO PYRIMIDINE DERIVATIVES

-

, (2013/03/26)

The present invention relates to pyrazolo pyrimidine derivatives, to methods of preparing these, to combinations and pharmaceutical composition comprising these, and to their use in the treatment of diseases and disorders which may for example involve autoimmune diseases, angiogenesis, pain, and/or inflammatory diseases.

Post a RFQ

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

1

What can I do for you?
Get Best Price

Get Best Price for 1401728-87-7