140184-19-6

Basic information

• Product Name: 5-(3-BroMobenzyl)-2,2-diMethyl-1,3-dioxane-4,6-dione
• Synonyms: 5-(3-BroMobenzyl)-2,2-diMethyl-1,3-dioxane-4,6-dione
• CAS NO: 140184-19-6
• Molecular Formula: C₁₃H₁₃BrO₄
• Molecular Weight: 313.14392
• Mol File: 140184-19-6.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 5-(3-BroMobenzyl)-2,2-diMethyl-1,3-dioxane-4,6-dione(CAS DataBase Reference)
• NIST Chemistry Reference: 5-(3-BroMobenzyl)-2,2-diMethyl-1,3-dioxane-4,6-dione(140184-19-6)
• EPA Substance Registry System: 5-(3-BroMobenzyl)-2,2-diMethyl-1,3-dioxane-4,6-dione(140184-19-6)

Safety Data

• Hazardous Substances Data: 140184-19-6(Hazardous Substances Data)

Upstream product

• 2033-24-1 cycl-isopropylidene malonate 
• 3132-99-8 m-bromobenzoic aldehyde 

Downstream Products

• 1167473-11-1 2-(3-bromobenzyl)malonic acid ethyl ester methyl ester 
• 125114-77-4 7-bromo-2,3-dihydro-1H-inden-1-one 
• 34598-49-7 5-Bromo-1-indanone 
• 42287-90-1 3-(3-bromophenyl)propanoic acid 

Relevant articles and documents

Multi-catalysis cascade reactions based on the methoxycarbonylketene platform: Diversity-oriented synthesis of functionalized non-symmetrical malonates for agrochemicals and pharmaceuticals

In this paper we describe new multi-catalysis cascade (MCC) reactions for the one-pot synthesis of highly functionalized non-symmetrical malonates. These metal-free reactions are either five-step (olefination/hydrogenation/alkylation/ ketenization/esterif

Efficient synthesis of halo indanones via chlorosulfonic acid mediated Friedel-Crafts cyclization of aryl propionic acids and their use in alkylation reactions

Several halo indanones were synthesized from benzyl Meldrum's acid derivatives in two steps. Although several Lewis acids are effective for the Friedel-Crafts ring-closing reaction on more electron-rich arenes, in the case of the electron-deficient arenes this chemistry is not efficient. Here it is reported that chlorosulfonic acid (used as solvent) is an efficient reagent for cyclization of electron-withdrawing arenes. These molecules are potentially useful for subsequent alkylation reactions. The selective alkylation of 5,7-dibromo indanone is demonstrated using Pd-catalyzed Grignard coupling to provide monoalkylated indanone in good yield.