1401880-75-8Relevant academic research and scientific papers
Carbene-catalyzed aerobic oxidation of isoquinolinium salts: Efficient synthesis of isoquinolinones
Wang, Guanjie,Hu, Wanyao,Hu, Zhouli,Zhang, Yuxia,Yao, Wei,Li, Lin,Fu, Zhenqian,Huang, Wei
supporting information, p. 3302 - 3307 (2018/07/29)
A mild and environmentally friendly carbene-catalyzed aerobic oxidation of isoquinolinium salts was successfully realized. Accordingly, a diverse set of isoquinolinones and phenanthridinones was efficiently prepared in good to excellent yields. The mechanistic study indicates that the formation of an aza-Breslow intermediate is the crucial step in this transformation. This reaction features ambient air as the sole oxidant and oxygen source, a broad substrate scope, and excellent functional-group tolerance and proceeds under mild reaction conditions. Furthermore, a highly efficient synthesis of bioactive molecules and natural products including N-methylcrinasiadine, N-isopentylcrinasiadine, N-phenethylcrinasiadine, isoindolo[2,1-b]isoquinolin-5(7H)-one, PJ-34, rac-Gusanlung D, rosettacin, 8-oxopseudopalmatine and ilicifoline B was accomplished.
Palladium-catalyzed annulation of benzynes with N-substituted-N-(2- halophenyl)formamides: Synthesis of phenanthridinones
Yang, Yuan,Huang, Hui,Wu, Lijun,Liang, Yun
, p. 5351 - 5355 (2014/07/21)
A novel and efficient procedure for the synthesis of N-substituted phenanthridinones via palladium-catalyzed annulation of benzynes with N-substituted-N-(2-halophenyl)formamides has been developed. This methodology constructs two new C-C bonds via an arylation/annulation process, and provides the desired products in good yields. This journal is the Partner Organisations 2014.
Palladium-catalyzed annulation of arynes by o-halobenzamides: Synthesis of phenanthridinones
Lu, Chun,Dubrovskiy, Anton V.,Larock, Richard C.
, p. 8648 - 8656 (2012/11/07)
The palladium-catalyzed annulation of arynes by substituted o-halobenzamides produces N-substituted phenanthridinones in good yields. This methodology provides this important heterocyclic ring system in a single step by simultaneous C-C and C-N bond formation, under relatively mild reaction conditions, and tolerates a variety of functional groups.
