140192-89-8Relevant academic research and scientific papers
Identification of novel and potent isoquinoline aminooxazole-based IMPDH inhibitors
Chen, Ping,Norris, Derek,Haslow, Kristin D.,Dhar, T. G. Murali,Pitts, William J.,Watterson, Scott H.,Cheney, Daniel L.,Bassolino, Donna A.,Fleener, Catherine A.,Rouleau, Katherine A.,Hollenbaugh, Diane L.,Townsend, Robert M.,Barrish, Joel C.,Iwanowicz, Edwin J.
, p. 1345 - 1348 (2007/10/03)
Screening of our in-house compound collection led to the discovery of 5-bromo-6-amino-2-isoquinoline 1 as a weak inhibitor of IMPDH. Subsequent optimization of 1 afforded a series of novel 2-isoquinolinoaminooxazole-based inhibitors, represented by 17, with single-digit nanomolar potency against the enzyme.
Antiparasitic agents: Part XV - Synthesis of 2-substituted 1(3)H-imidazoisoquinolines as anthelmintic agents
Kumar, Pramod,Agarwal, Shiv K,Bhakuni, D S
, p. 177 - 182 (2007/10/02)
5-(2,4-Dioxo-1H-quinazolin-3-yl)isoquinoline (14) and 2-(methyl-/carbomethoxyamino-/furyl-/trifluoromethyl)-1(3)H-imidazoisoquinolines (17, 20-22) have been synthesized and tested for their anthelmintic and antifilarial activities against Ancylosto
