1402003-92-2

Upstream product

• 15191-69-2 4-(2-methoxyphenyl)-1,1,1-trifluoro-2,4-butanedione 
• 753-90-2 trifluoroethylamine 
• 767-91-9 1-ethynyl-2-methoxybenzene 
• 579-74-8 2-Methoxyacetophenone 

Relevant academic research and scientific papers

Cu-Catalyzed Synthesis of Fluoroalkylated Isoxazoles from Commercially Available Amines and Alkynes

A one-pot protocol for the construction of fluoroalkylated isoxazoles directly from commercially available amines and alkynes is described. The reaction is scalable, operationally simple, regioselective, mild, and tolerant of a broad range of functional groups. As such, it could be viewed as a click synthesis of fluoroalkylated isoxazoles. Preliminary mechanistic investigations reveal that the transformation involves an unprecedented Cu-catalyzed cascade sequence involving RfCHN2.

Novel Bicyclic Pyridinones

Compounds and pharmaceutically acceptable salts of the compounds are disclosed, wherein the compounds have the structure of Formula I as defined herein. Corresponding pharmaceutical compositions, methods of treatment, methods of synthesis, and intermediates are also disclosed.