1402077-46-6Relevant articles and documents
Simple analogues of qinghaosu (artemisinin)
Li, Yun,Hao, Hong-Dong,Wittlin, Sergio,Wu, Yikang
, p. 1881 - 1886 (2012/09/07)
A series of 1,2,4-trioxanes were synthesized in which the key peroxy bonds were installed through a molybdenum-catalyzed perhydrolysis of the epoxy rings. A core structure was identified that may serve as a promising lead structure for further investigations because of its high antimalarial activity (comparable to that of artesunate and chloroquine), apparent potential for scale-up and derivatization, and facile monitoring/tracing by using UV light.