140211-06-9Relevant academic research and scientific papers
Azabicyclic compounds are central nervous system active agents
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Page 58, (2010/02/05)
Compounds of formula (I) are novel CNS active agents that are useful for treating pain and for treating other disorders associated with the cholinergic system.
Synthesis and antibacterial activity of new 7-(aminoazabicycloalkanyl)quinolonecarboxylic acids
Ogata, M,Matsumoto, H,Shimizu, S,Kida, S,Nakai, H,et al.
, p. 889 - 906 (2007/10/02)
A series of novel 7--6-fluoro-1-substituted quinolinecarboxylic acids (18-53) have been prepared and their antibacterial activities evaluated.These compounds are characterized structurally by a new amino-substituted azabicyclooctane, -nonane and -decane ring systems at the 7-position of quinolonecarboxylic acids.To compare the biological activities of enantiomers, (+)-7-octan-3-yl>-1-cyclopropyl-6,8-difluoro-1,4-dihydro-4-oxo-3-quinolonecarboxylicacid hydrochloride (43, 44) were synthesized and evaluated for antibacterial activity.Compound 43 was more potent than 44 against both Gram-positive and Gram-negative organisms.The structure-activity relationships of these quinolonecarboxylic acids are also discussed. antibacterial activity / amino-substituted azabicycloalkane ring / substituted quinolonecarboxylic acids / structure-activity relationships
