1402140-68-4

Upstream product

• 1402140-57-1 (1Z)-1,3-diphenyl-2-propyn-1-one O-[(4-methoxyphenyl)-methyl]oxime 
• 71-36-3 butan-1-ol 
• 1402140-77-5 (1Z)-1,3-diphenyl-2-propyn-1-one O-[[4-[[(1,1-dimethylethyl)-dimethylsilyl]oxy]phenyl]methyl]oxime 
• 1402140-58-2 (1Z)-1-[4-(trifluoromethyl)phenyl]-3-phenyl-2-propyn-1-one O-[(4-methoxyphenyl)methyl]oxime 
• 21038-22-2 O-(4-methoxybenzyl)hydroxylamine 
• 7338-94-5 1,3-diphenyl-2-propynone 
• 98-80-6 phenylboronic acid 
• 94-02-0 ethyl 3-oxo-3-phenylpropionate 
• 1076-59-1 3-phenyl-4H-isoxazol-5-one 

Relevant academic research and scientific papers

Suzuki-Miyaura cross-coupling of 3,4-disubstituted 5-bromoisoxazoles: An efficient access to trisubstituted isoxazoles

The Suzuki-Miyaura cross-coupling of 3,4-disubstituted 5-bromoisoxazoles 1 at the C5 position has successfully proceeded in the presence of Pd2(dba)3 and P(t-Bu)3·HBF4 catalysts to give the corresponding trisubstituted isoxazoles 3 in good to high yields while suppressing the formation of ketone 4 as a byproduct. The use of bulky phosphine ligand P(t-Bu)3·HBF4 is essential for the current transformation, and the formation of ketone 4, which was a major product in the previous report, was able to be suppressed under the current conditions.

Copper-catalyzed synthesis of trisubstituted isoxazoles via a cascade cyclization-migration process

An atom-economical, catalytic, and regioselective synthesis of 3,4,5-trisubstituted isoxazoles has been successfully developed. Treatment of O-arylmethyl alkynyl oxime ethers with 5 mol % of Cu(OTf)2 in chlorobenzene at reflux gave 4-arylmethylisoxazoles in good to excellent yields via the sequential intramolecular addition of the oxime moiety to the alkyne with subsequent 1,3-migration of the arylmethyl group.