140226-27-3

Upstream product

• 50-90-8 5-chloro-2'-deoxyuridine 
• 111476-39-2 5-chloro-2',5'-dideoxy-5'-iodouridine 
• 139426-40-7 5-chloro-1-(2,5-dideoxy-β-D-glycero-pent-4-enofuranosyl)uracil 
• 100-07-2 4-methoxy-benzoyl chloride 
• 139419-03-7 1-(4-azido-2,5-dideoxy-5-iodo-β-D-erythro-pentofuranosyl)5-chloro-2,4-dioxopyrimidine 

Downstream Products

• 139418-97-6 4'-azido-5-chloro-2'-deoxyuridine 

Relevant academic research and scientific papers

Antiviral agents

Nucleoside compounds of the formula STR1 wherein: B is a purine or a pyrimidine; X and X' are H, OH or F, provided that at least one is H; Y and Y' are H, OH, OCH3 or F, provided that at least one is H; Y' and Z together form a cyclic phosphate ester, provided that Y is H; or Z is STR2 where n is zero, one, two or three; and Z' is N3 or OCH3 ; provided that when X' and Y' are OH and Z' is N3, B is not cytosine, and when X' and Y' are OH and Z' is OCH3, B is not uracil, adenine or cytosine; and the pharmaceutically acceptable esters, ethers and salts thereof, have been found to have potent antiviral activity with a high therapeutic ratio.

Synthesis and anti-HIV activity of 4'-azido- and 4'-methoxynucleosides

A series of nucleosides were synthesized in which the 4'-hydrogen was substituted with either an azido or a methoxy group. The key steps in the syntheses of the 4'-azido analogues were the stereo- and regioselective addition of iodine azide to a 4'-unsatu