1402299-58-4Relevant academic research and scientific papers
Far-Red and Near-IR AIE-Active Fluorescent Organic Nanoprobes with Enhanced Tumor-Targeting Efficacy: Shape-Specific Effects
Shao, Andong,Xie, Yongshu,Zhu, Shaojia,Guo, Zhiqian,Zhu, Shiqin,Guo, Jin,Shi, Ping,James, Tony D.,Tian, He,Zhu, Wei-Hong
, p. 7275 - 7280 (2015)
The rational design of high-performance fluorescent materials for cancer targeting in vivo is still challenging. A unique molecular design strategy is presented that involves tailoring aggregation-induced emission (AIE)-active organic molecules to realize preferable far-red and NIR fluorescence, well-controlled morphology (from rod-like to spherical), and also tumor-targeted bioimaging. The shape-tailored organic quinoline-malononitrile (QM) nanoprobes are biocompatible and highly desirable for cell-tracking applications. Impressively, the spherical shape of QM-5 nanoaggregates exhibits excellent tumor-targeted bioimaging performance after intravenously injection into mice, but not the rod-like aggregates of QM-2.
