140236-11-9

Upstream product

• 107-86-8 3,3-dimethyl acrylaldehyde 
• 104-94-9 4-methoxy-aniline 

Downstream Products

• 178250-07-2 (3R,4S)-1-(4-methoxyphenyl)-3-triisopropylsiloxy-4-(2-methylprop-1-enyl)azetidin-2-one 
• 186347-95-5 2'-(triisopropylsilyl)-3'-dephenyl-3'-(2-methyl-1-propenyl)-7-(triethylsilyl)-10-(cyclopropylcarbonyl)-14β-hydroxydocetaxel 1,14-carbonate 
• 186347-96-6 2'-(triisopropylsilyl)-3'-dephenyl-3'-(2-methyl-1-propenyl)-7-(triethylsilyl)-10-(N,N-dimethylcarbamoyl)-14β-hydroxydocetaxel 1,14-carbonate 
• 186347-99-9 2'-(triisopropylsilyl)-3'-dephenyl-3'-(2-methyl-1-propenyl)-7-(triethylsilyl)-10-(methoxycarbonyl)-14β-hydroxydocetaxel 1,14-carbonate 
• 186348-02-7 2'-(triisopropylsilyl)-3'-dephenyl-3'-(2-methyl-1-propenyl)-3'-N-hexanoyl-7-(triethylsilyl)-10-(cyclopropylcarbonyl)-14β-hydroxydocetaxel 1,14-carbonate 
• 186348-03-8 2'-(triisopropylsilyl)-3'-dephenyl-3'-(2-methyl-1-propenyl)-3'-N-hexanoyl-7-(triethylsilyl)-10-(N,N-dimethylcarbamoyl)-14β-hydroxydocetaxel 1,14-carbonate 
• 186347-98-8 2'-(triisopropylsilyl)-3'-dephenyl-3'-(2-methyl-1-propenyl)-7-[(triethylsilyl)oxy]-10-((E)-2-butenoyl)-14β-hydroxydocetaxel 1,14-carbonate 
• 186347-94-4 2'-(triisopropylsilyl)-3'-dephenyl-3'-(2-methyl-1-propenyl)-7-(triethylsilyl)-10-propanoyl-14β-hydroxydocetaxel 1,14-carbonate 
• 186348-04-9 2'-[(triisopropylsilyl)oxy]-3'-dephenyl-3'-(2-methyl-1-propenyl)-3'-N-hexanoyl-7-(triethylsilyl)-10-((E)-2-butenoyl)-14β-hydroxydocetaxel 1,14-carbonate 
• 186347-93-3 2'-(triisopropylsilyl)-3'-dephenyl-3'-(2-methyl-1-propenyl)-7-(triethylsilyl)-10-acetyl-14β-hydroxydocetaxel 1,14-carbonate 
• 186348-11-8 3'-dephenyl-3'-(2-methyl-1-propenyl)-10-(N,N-dimethylcarbamoyl)-14β-hydroxydocetaxel 1,14 carbonate 

Relevant academic research and scientific papers

Fluorinated taxane compound, preparation method therefor and application of fluorinated taxane compound

The invention discloses a fluorinated taxane compound, a preparation method therefor and an application of the fluorinated taxane compound. The compound has a structural general formula represented bya formula I. Proven by pharmacological experiments, compared with paclitaxel, a series of fluorinated taxane derivatives synthesized by the method have cytotoxicity superior to that of the paclitaxelto a multidrug-resistant human mammary cancer cell line MCF-7/Adr and an ovarian cancer cell line NCI/Adr and represent cytotoxicity superior to that of the paclitaxel to a colon cancer cell line HCT-116 with overexpressed neoplasm stem cells.

Syntheses and structure-activity relationships of taxoids derived from 14β-hydroxy-10-deacetylbaccatin III

A series of new taxoids derived from 14β-hydroxy-10-deacetylbaccatin III was synthesized by means of the β-lactam synthon method. Most of the new taxoids thus synthesized possess excellent cytotoxicity against human ovarian (A121), non-small-cell lung (A5