140241-75-4Relevant academic research and scientific papers
Copper-mediated cross-coupling-cyclization-oxidation: A one-pot reaction to construct polysubstituted pyrroles
Liu, Pei,Liu, Jin-Ling,Wang, Heng-Shan,Pan, Ying-Ming,Liang, Hong,Chen, Zhen-Feng
supporting information, p. 4795 - 4798 (2014/05/06)
A novel and efficient procedure for the synthesis of polysubstituted pyrroles has been developed in this work. The polysubsituted pyrroles were synthesized directly from terminal alkenes, amines and β-keto esters through cross-coupling-cyclization-oxidation in the presence of a catalytic amount of cuprous chloride. This method provides a one-pot synthesis route from terminal alkenes to polysubstituted pyrroles for the first time and opens a new area in cuprous catalysis. The Royal Society of Chemistry 2014.
Regioselectivity in the 1,3-dipolar cycloaddition of muenchnones with two electrophilic alkynes. Attempt of rationalization.
Texier, F.,Mazari, M.,Yebdri, O.,Tonnard, F.,Carrie, R.
, p. 962 - 967 (2007/10/02)
The 1,3-dipolar cycloaddition reaction of several unsymmetrically substituted muenchnones with methyl propiolate 3a and with methyl 3-phenylpropiolate 3b has been examined.The reaction generally proceeds with formation of mixtures of both possible regioisomeric pyrroles.The dipolarophile 3b is more selective than 3a in accordance with the literature.Sustmann's variation-perturbation theory could not account for the observed regioselectivities, this theory gives correct predictions with alkenes as we have shown recently. 1,3-cycloaddition / muenchnones / pyrroles / regioselectivity
